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New Heart-Saving tactic tested in surgery

NCT ID NCT03230136

Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a special heart-protection method given during heart surgery to see if it could reduce damage to the heart muscle. 210 adults having aortic valve surgery took part. Researchers measured a protein called troponin I in the blood for 72 hours after surgery to check for heart injury.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

210 people

The number who actually took part.

Started

Jan 2018

Finished

Jul 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 18 years old * Aortic valve surgery (aortic valve replacement associated or not with coronary artery bypass graft, Bentall surgery or Tirone David surgery) * Signed informed consent Exclusion Criteria: * Emergency surgery * Redo surgery * Patient treated with Nicorandil, repaglinid or sulfonylurea 48 hours prior to surgery * Low cardiac output requiring catecholamine infusion or circulatory assistance prior to surgery * Severe renal failure: dialysis or glomerular filtration rate \< 30 mL/min * Severe liver failure (spontaneous INR \>2) * Severe respiratory insufficiency (VEMS \<40% of predicted value) * Contra-indication to sevoflurane and propofol * Myocardial infarction \< 7 days * Severe upper limb arterial disease * Heparin-induced thrombopenia * Active infection under antibiotic treatment * Any other surgery combined with the aortic valve surgery: myotomia of Morrow (hypertrophic myocardiopathy), treatment of heart rhythm disorder, inter-atrial communication closure, mitral valve replacement, tricuspid valve replacement, pulmonary valve replacement. * Pregnant women * Currently participating in another trial which may interfere with ProCCard results * Not benefiting from a social insurance or similar system * Patient under legal protection

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Conditions

The condition(s) this trial relates to.

aortic valve disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiopulmonary bypass Thoracic surgery

Contacts and locations

Locations

  • CH Annecy

    Annecy, France

  • CHU Saint-Etienne

    Saint-Etienne, France

  • CHU de Caen

    Caen, France

  • Clinique de la sauvegarde

    Lyon, France

  • Institut Arnault Tzanck - Saint-Laurent du Var

    Saint-Laurent-du-Var, France

  • Service d'Anesthésie-Réanimation, Hôpital Cardiologique et Pneumologique Louis Pradel

    Bron, 69500, France

  • Unité de Réanimation Cardiovasculaire et Thoracique, Hôpital Michallon

    Grenoble, France

  • service de Chirurgie Cardiaque CHU Gabriel Montpied

    Clermont-Ferrand, France

More trials for these conditions

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