Alveolar capillary dysplasia with misalignment of pulmonary veins

This pilot study tests whether putting back a child's own thymus tissue during heart surgery is safe and helps support the immune system. In some congenital heart disease surgeries, the thymus is removed to reach the heart, which may weaken immunity. Researchers will compare chil…

This trial tests whether a digital rehabilitation programme called I-IMPACT can be a practical alternative to traditional centre-based pulmonary rehabilitation for adults with interstitial lung disease (ILD). The study will compare the two approaches, focusing on feasibility—such…

This trial tests whether adding a blood-filtering device, called hemoadsorption, to the heart-lung machine can reduce harmful inflammation in children undergoing complex open-heart surgery. The device is designed to remove inflammatory proteins, known as cytokines, from the blood…

This trial tests whether a personalized exercise program before heart surgery can improve physical fitness in adults with congenital heart disease. Participants are randomly assigned to either usual care or a 6-week prehabilitation plan with aerobic, breathing, and strength exerc…

This study will test if a smart pill bottle cap, called FORTISKAP™, helps people with serious lung diseases like pulmonary fibrosis, sarcoidosis, and pulmonary hypertension take their oral medications more consistently. About 100 participants will either use the smart cap or rece…

Researchers in Qinghai Province, China, are testing whether artificial intelligence can help primary care doctors spot congenital heart disease during school-based screening. Schools are randomly assigned to either standard listening with a stethoscope or listening plus AI analys…

Researchers at Mayo Clinic are testing an investigational radioactive tracer called 68Ga-FAPI-46 to see how it distributes in the lungs of people with interstitial lung disease. About 10 participants with a clinical diagnosis of ILD and lung abnormalities on a recent CT scan rece…

Researchers at Assiut University Hospitals are studying how well fetal heart scans before birth match the heart diagnoses babies receive after delivery. The study includes pregnant women referred for fetal echocardiography and newborns with confirmed critical congenital heart dis…

Researchers are testing a noninvasive MRI technique that uses inhaled hyperpolarized xenon gas to measure lung function in adults with interstitial lung disease, pulmonary hypertension, and systemic sclerosis. The study includes about 51 participants, including healthy volunteers…

This study enrolls children and young adults scheduled for heart surgery or catheterization under general anesthesia. Researchers place a forehead sensor that measures tissue oxygen levels and use an algorithm to estimate blood hemoglobin. The goal is to see if this noninvasive m…

This study will check how accurate chest X-rays are at finding congenital heart disease in newborns. Researchers will study 60 babies in the NICU who show signs of heart problems. Each baby gets a chest X-ray within 24 hours and an echocardiogram within 72 hours. By comparing the…

Children scheduled for angiography often feel anxious, which can affect their heart rate, blood pressure and cooperation during the procedure. This trial tests whether a short virtual reality guided breathing exercise, delivered through a headset showing calming scenery, can redu…

This study tests whether a virtual reality (VR) program that guides slow, controlled breathing and arm exercises can help people with interstitial lung disease (ILD) manage symptoms like breathlessness and fatigue. Participants will either use a VR headset or follow printed instr…

This study tests whether a supervised Clinical Pilates program can improve physical function, breathing, and quality of life in 58 adults with interstitial lung disease (ILD). Participants are randomly assigned to either Pilates sessions plus standard care or standard care alone.…

Interstitial lung diseases cause lung scarring and stiffness, making it hard to breathe. This study will test whether an 8-week pulmonary rehabilitation program—including walking, cycling, and strength exercises—can improve diaphragm function, exercise ability, and quality of lif…

This observational study tests whether a new device, the SpectroCor Tissue Oxygenation Monitor, can accurately track oxygen levels in the heart muscle of children undergoing open-heart surgery. The device uses a sensor placed on the heart to measure oxygen availability during key…

People with interstitial lung disease (ILD) can suddenly get much worse, but it is hard to tell if the cause is a lung flare-up or a blood clot in the lungs (pulmonary embolism). This observational study will follow 70 adults with ILD who come to the hospital with worsening breat…

This study will track 427 adults with interstitial lung disease (ILD) who need a bronchoscopy as part of their care. Researchers want to see how often complications happen within 30 days after the procedure. The goal is to better understand the risks so doctors can make safer cho…

This study will test a handheld device called IntraOx that uses light to measure oxygen levels in heart and liver tissue during complex heart surgery in children. The goal is to see if it can give surgeons useful information about blood flow without interfering with the operation…

This study looks at how the antibiotic cefazolin spreads in the chest tissue of 10 children after heart surgery for congenital heart disease. A small probe placed during surgery will measure drug levels over 36 hours. The goal is to create a computer model to help doctors give th…

This study will test a new, non-invasive ultrasound technique that captures brain blood flow in real time for infants with congenital heart disease. Researchers aim to understand how medical treatments and surgeries affect the brain, potentially explaining why some children later…

This study will use a procedure called bronchoalveolar lavage (BAL) to collect fluid from the lungs of 66 adults with suspected interstitial lung disease (ILD). The fluid will be analyzed to identify specific inflammatory cells, which may help doctors distinguish between differen…