Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Tiny probe tracks antibiotic in Kids' chests after heart surgery

NCT ID NCT07327502

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how the antibiotic cefazolin spreads in the chest tissue of 10 children after heart surgery for congenital heart disease. A small probe placed during surgery will measure drug levels over 36 hours. The goal is to create a computer model to help doctors give the best dose to prevent infections.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cefazolin
What this could lead to
If successful, this could help doctors give the right dose of cefazolin to prevent infections after children's heart surgery.
What could go wrong
This is a very small, early study with only 10 children, so results may not apply to all kids. It only measures drug levels, not whether infections are actually prevented.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 10 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2026

An estimate. Start dates often move.

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 months to 6 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Child aged over 6 months and under 6 years * Hospitalized in pediatric cardiac intensive care after cardiac surgery for congenital heart disease. * Selected congenital heart diseases: ventricular septal defect auricular septal defect, pulmonary stenosis, tetralogy of Fallot * Surgery with median sternotomy and intraoperative cardiopulmonary bypass * Intraoperative antibiotic prophylaxis with cefazolin * Patient affiliated with a social security plan or eligible * whose two parents or legal guardians have accepted and signed the study consent Exclusion Criteria: * Emergency cardiac surgery * Patient already enrolled in the study * Patient who has previously undergone cardiac surgery * Patient with haemostasis disorders or immune deficiency * Patient with bacterial colonization indicating antibiotic prophylaxis other than cefazolin * Participation in another interventional research study

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Children in cardiac intensive care requiring surgery for congenital heart disease are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

congenital heart disease mediastinitis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Children in cardiac intensive care requiring surgery for congenital heart disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hôpital Necker Enfants Malades

    Paris, Île-de-France Region, 75015, France