Adrenocortical insufficiency

Researchers are testing whether hydrocortisone granules (Infacort) mixed with yoghurt or soft food get into the bloodstream as well as dry granules placed on the back of the tongue. The study enrolls 19 healthy adult men whose natural cortisol is temporarily suppressed with dexam…

Researchers are testing whether a granule form of hydrocortisone called Infacort is absorbed into the body as well as standard hydrocortisone tablets (Cortef). The study enrolls healthy adults aged 18 to 55 and gives each participant both forms in a random order, once while fasti…

Researchers are testing Chronocort, a modified-release form of hydrocortisone, against standard immediate-release hydrocortisone in 30 healthy male volunteers. The study measures how the drug moves through the body, including how fast it reaches peak levels and how long it stays …

Researchers are comparing two modified-release hydrocortisone pills, Chronocort and Plenadren, in adults with primary adrenal insufficiency, a condition where the adrenal glands do not make enough cortisol. The study is a phase 2, double-blind, crossover trial: participants recei…

Researchers are testing several modified, timed-release versions of hydrocortisone, a hormone drug, in healthy male volunteers. The study has two parts: one compares how six different formulations move through the body after a single nighttime dose, and the other checks whether t…

Researchers are testing how the body absorbs Chronocort, a modified-release hydrocortisone, compared with Cortef, a standard immediate-release hydrocortisone tablet. The study enrolls healthy adult men whose natural cortisol production is temporarily suppressed with dexamethasone…

This study tested a new oral drug called atumelnant in 38 adults with classic congenital adrenal hyperplasia, a genetic condition causing hormone imbalances. The drug works by blocking a hormone receptor to lower excess adrenal hormones. Researchers measured safety, side effects,…

This study looked at the long-term safety of a medication called Chronocort in 76 people aged 16 and older with congenital adrenal hyperplasia (CAH), a condition where the body can't make enough cortisol. Researchers monitored for signs of over- or under-treatment, adrenal crises…

This study tested whether giving low doses of two steroids (hydrocortisone and fludrocortisone) helps adults with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. 380 participants received either the steroids or a placebo. The main goal was…

This study tested a special stent graft (E-liac) to treat bulges in the iliac artery (aneurysms) without open surgery. 71 patients received the device, sometimes combined with other aortic grafts. The main goal was to prevent aneurysm rupture and death. Researchers tracked succes…

This phase 2 trial tested a new drug called SPR001 in 24 adults with classic congenital adrenal hyperplasia (CAH), a genetic condition that disrupts hormone production. The study aimed to see if SPR001 is safe and can improve hormone control. Participants took multiple doses of t…

This study looks at how the adrenal glands work in people who are critically ill, such as those with sepsis. Adrenal insufficiency may affect up to 77% of ICU patients, but current tests are not reliable. Researchers will measure hormone levels in 225 participants, including heal…

This study looked at how the body's natural endocannabinoids (similar to cannabis compounds) interact with the stress hormone cortisol in people with Cushing's syndrome, a condition of high cortisol. Researchers measured blood levels of these compounds in 40 participants, includi…

This completed study looked at newborn screening for congenital adrenal hyperplasia (CAH) in Italy. Researchers reviewed medical records of 29 infants diagnosed with classic CAH between 2006 and 2019 to see how accurate the screening was. The goal was to measure the screening's s…

This study looked at how often children with a rare adrenal gland problem (congenital adrenal insufficiency) experience dangerously low blood sugar. Even with standard treatment, these children may have low blood sugar without obvious symptoms. Researchers monitored 9 children ag…

This completed study gave 22 healthy men a single dose of semaglutide (Rybelsus) or a placebo pill to see how it affects cortisol and other stress hormones. The goal was not to treat any disease, but to learn more about how GLP-1 drugs interact with the body's stress system. Part…

This study evaluates the long-term cognitive development of children who were exposed to dexamethasone (a steroid) while in the womb because they were at risk for congenital adrenal hyperplasia (CAH). The goal is to see if the drug causes any thinking or memory problems. Research…

This completed study investigated why patients with Cytochrome P450 Oxidoreductase (POR) deficiency, a rare genetic condition, often develop high blood pressure and blood vessel damage. Researchers compared 51 participants (patients and healthy controls) using 24-hour blood press…