Diabetes drug semaglutide may influence cortisol levels, small study suggests
NCT ID NCT06608433
First seen Feb 12, 2026 · Last updated Jun 21, 2026 · Updated 21 times
Summary
This completed study looked at how a single dose of semaglutide (Rybelsus), a drug used for diabetes and weight loss, affects cortisol and other stress hormones in healthy men. Twenty-two volunteers received either semaglutide or a placebo pill, and researchers measured changes in their cortisol levels. The goal was purely to learn more about the body's stress response, not to treat any disease.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
-
University Hospital Basel
Basel, Switzerland
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
semaglutide (Rybelsus)
What this could lead to
If it works, this could help doctors understand how GLP-1 drugs like semaglutide affect stress hormones and adrenal function.
What could go wrong
This is a very small, early study in healthy volunteers, not patients. It only tests a single dose and is not designed to treat or diagnose any condition.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.