Acute respiratory failure

This study follows about 1,756 adults who were part of a larger trial and received either ketamine or etomidate during emergency intubation. Researchers want to see if ketamine can reduce PTSD symptoms one year later, since it may block the brain's formation of traumatic memories…

This study is testing whether giving each patient on a ventilator a personalized oxygen target (based on their unique health data) leads to better outcomes than standard care. Researchers will compare death rates and time spent on the ventilator between the two groups. The trial …

This study tests whether training ICU staff to keep oxygen levels between 90-96% helps patients on breathing machines recover faster. Researchers will track how many days patients are free from the ventilator and how often dangerously low oxygen goes unnoticed. The goal is to imp…

This study looks at whether using a smaller breathing tube during emergency intubation helps critically ill adults breathe easier and have better voice and swallowing six months later. About 3,180 patients in emergency rooms and intensive care units will be randomly assigned to g…

This study analyzes data from over 1,200 patients with acute hypoxemic respiratory failure who were on breathing machines in Spanish ICUs. Researchers are using a statistical method called mediation analysis to determine whether low oxygen levels directly cause death, or whether …

This trial compares two types of video laryngoscope blades—hyperangulated and standard geometry—in critically ill adults who need a breathing tube in the emergency department or intensive care unit. About 2,500 participants will be randomly assigned to one blade type. The main go…

This study is testing whether a computer can automatically measure how much lung tissue is damaged in patients with severe breathing problems from COVID-19 or after surgery. Researchers will compare the computer's lung measurements to standard severity scores in 500 patients. The…

This study observes how the diaphragm works in 100 adults with acute respiratory failure who need non-invasive breathing support or high-flow oxygen. Researchers use ultrasound to measure diaphragm movement and thickness at different support levels. The goal is to understand how …

This study looks at different training methods for ICU staff to improve how they remove breathing tubes from patients. It involves over 13,000 adults on ventilators for more than 24 hours. The goal is to see if better education and care plans can reduce deaths and increase use of…

This study looks at two ways to help people in the ICU who have trouble breathing due to low oxygen levels. It compares using a helmet-like device plus high-flow oxygen through the nose versus high-flow oxygen alone. The goal is to see which approach works better and to gather in…

This study looks at a care approach called a time-limited trial (TLT) for ICU patients who need a breathing machine. Doctors, patients, and families agree to try treatments for a set time, then check if the patient is recovering. The goal is to see if this approach can reduce ICU…

This study looks at 500 patients with severe breathing failure due to pneumonia who are using a non-invasive breathing mask. Researchers will measure their energy needs, muscle function, and blood markers to identify different patient types. The goal is to better understand how t…

This study tests whether temperature sensors placed inside a Venturi mask can monitor breathing patterns in 82 patients hospitalized with pneumonia and respiratory failure. The goal is to see if these patterns can detect early signs of deterioration before patients need a breathi…