Acute pancreatitis

Severe acute pancreatitis causes the pancreas to swell dangerously, and pressure building inside the abdomen can lead to organ failure. Researchers at a Shanghai hospital are testing whether adding Da-Cheng-Qi Decoction, a classic Chinese herbal formula, to standard Western treat…

Researchers test a blood purification device called Efferon CT combined with high-volume hemofiltration in adults with acute pancreatitis. The goal is to see if removing inflammatory molecules from the blood reduces organ dysfunction and improves recovery. The trial enrolls 28 pa…

This study tested a drug called Auxora in 216 people hospitalized with acute pancreatitis and systemic inflammatory response syndrome (SIRS), a serious body-wide inflammation. Participants received either Auxora or a placebo daily for three days. The main goal was to see if Auxor…

This trial tests whether the type of IV fluid given to people with acute pancreatitis affects how severe the disease becomes. About 800 adults with acute pancreatitis will be randomly assigned to receive either lactated Ringer's solution or normal saline for at least 48 hours. Th…

This trial tests whether epidural analgesia—pain medicine delivered near the spinal cord—can help people with severe acute pancreatitis breathe better and avoid needing a breathing machine. About 148 ICU patients with severe pancreatitis will be randomly assigned to receive eithe…

This study tests whether adding a traditional Chinese herbal enema (Tongfu Qinghua Decoction) and an external herbal powder (Ruyi Jinhuang Powder) to standard medical care can help adults with acute pancreatitis recover faster. The trial enrolled 100 people aged 18 to 75 with the…

This study tested whether injecting epinephrine around the bile duct opening, combined with a standard rectal anti-inflammatory drug, could reduce pancreatitis after ERCP—a common procedure to treat bile duct blockages. Over 500 adults with a first-time ERCP took part. The goal w…

This study tested an experimental drug called CM4620-IE in 21 people with severe pancreatitis that caused body-wide inflammation (SIRS). The goal was to see if the drug is safe and to find the best dose for future studies. Participants received the drug plus standard care or stan…

This study looked at whether using low-acid contrast media (dye) during ERCP can lower the chance of developing pancreatitis afterward. Researchers reviewed records of nearly 4,000 patients from five hospitals. They compared patients who received low-acid contrast media to those …

This study tested whether a low-dose CT scan, enhanced with deep learning image reconstruction, can diagnose acute abdominal conditions as accurately as a standard CT scan. 246 adults with abdominal pain received both scans, and the low-dose version used less than 30% of the usua…

This study looked at new markers in blood and urine to detect and predict the severity of drug-associated acute pancreatitis in adults. Researchers compared these markers in 175 patients with drug-induced pancreatitis, other pancreatic diseases, and healthy volunteers. The goal i…

This study tested whether giving rectal indomethacin (an anti-inflammatory drug) along with extra fluids before an ERCP procedure could prevent pancreatitis, a painful complication. The trial included 60 patients who needed ERCP. The goal was to see if this simple, low-cost appro…

This study tested whether taking oral N-Acetyl cysteine before an ERCP procedure could prevent pancreatitis as well as the standard treatment, rectal diclofenac. Forty-six adults at risk for pancreatitis after ERCP received one of the two drugs. The goal was to see which drug bet…

This study looked at 192 children having an ERCP procedure to see which drug—rectal indomethacin or IV ketorolac—better prevents post-ERCP pancreatitis. Both are anti-inflammatory medicines given before the procedure. The goal is to find the most effective option for kids.

This study looked at whether giving more IV fluids (aggressive hydration) during an ERCP procedure can prevent pancreatitis, a common complication. 126 adults having their first ERCP were randomly assigned to receive either standard or extra fluids. The goal was to see if extra f…

This study tested whether rinsing the duodenal papilla with cold (3°C) sterile saline right after an ERCP procedure can lower the risk of post-ERCP pancreatitis. 900 adults in Colombia were randomly assigned to receive the cold saline rinse or standard care. The main goal was to …

This study tested whether a procedure called ERCP with sphincterotomy can lower the risk of repeat pancreatitis attacks in people with pancreas divisum, a condition where the pancreas ducts don't join normally. 181 adults who had at least two pancreatitis episodes were randomly a…

This study tested a non-invasive device that stimulates a nerve in the ear (taVNS) to see if it can calm inflammation and improve gut function in people with acute pancreatitis. Sixty adults with early-stage pancreatitis received either the real stimulation or a sham device. The …

This study tested whether using forceps to help guide a tube into the bile duct during an ERCP procedure makes the process easier and reduces the chance of pancreatitis afterward. 152 patients were randomly assigned to either standard cannulation or forceps-assisted cannulation. …

This observational study will monitor 1,000 patients in Slovakia and Czechia who undergo ERCP, a procedure to treat bile duct problems. The main goal is to track how often pancreatitis occurs after the procedure and whether hospitals are following recommended prevention steps. Th…

This completed study looked at 141 people with acute pancreatitis to understand how blood clotting changes during the illness. Researchers took blood samples over several days and will analyze them for markers that might predict whether the disease becomes mild, moderate, or seve…

This study looked at how emergency general surgery affects pregnant women and their unborn babies. Researchers planned to follow pregnant women who needed surgery for problems like appendicitis or gallbladder disease. The goal was to learn more about the safety of these surgeries…

This study looked at 445 patients with mild acute biliary pancreatitis to compare having gallbladder removal surgery during the same hospital stay versus waiting for a later date. The goal was to see which approach leads to fewer repeat hospital visits for gallstone-related probl…