Ear zap eases pancreatitis pain? new study says maybe.
NCT ID NCT06998784
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a non-invasive device that stimulates a nerve in the ear (taVNS) to see if it can calm inflammation and improve gut function in people with acute pancreatitis. Sixty adults with early-stage pancreatitis received either the real stimulation or a sham device. The goal was to see if the treatment could reduce symptoms and speed up recovery.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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60 people
The number who actually took part.
- Started
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May 2025
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. AP patients aged 18-80 years. 2. PAN-PROMISE score ≥15 and no participation in any other clinical trials within the past 3 months. 3. AP patients who presented to the emergency department no more than 24 hours after symptom onset and who had received a diagnosis no more than 8 hours before enrollment. Exclusion Criteria: 1. Patients with an APACHE II score≥8, a C-reactive protein (CRP) level \> 150 mg/L, or organ failure at baseline (shock, respiratory failure, or renal failure) were excluded. 2. Presence of diseases or conditions different from AP that may interfere with the scale, for example, other causes of abdominal pain (especially acute cholecystitis), obstruction of the digestive tract (peptic pyloric stenosis, gastrointestinal anastomotic stenosis, diabetic gastroparesis, gastrointestinal neoplasia...), nausea-vomiting (brain tumour, chemotherapy...) or weakness (pre-existing anaemia with haemoglobin \<9 g/dL, heart failure or respiratory insufficiency associated with minimal effort dyspnoea, or domiciliary treatment with O2, advanced neoplasms or other debilitating diseases); 3. Implanted cardiac pacemaker or other electronic devices; 4. Prior treatment with transcutaneous auricular vagus nerve stimulation (taVNS); 5. Known malignancy; 6. Severe cardiovascular/cerebrovascular, hepatic, or renal diseases; 7. Cognitive impairment, psychiatric disorders, or other conditions that may affect patient cooperation; 8. Refusal to sign informed consent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Gastroenterology , Tangdu Hospital , Fourth Military Medical University
Xi'an, Shaanxi, 710038, China
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Department of Gastroenterology, 986 Hospital of Xijing Hospital, Fourth Military Medical University
Xi'an, Shaanxi, 710054, China
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Shaanxi Second People's Hospital
Xi'an, Shaanxi, 710000, China
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The 980th Hospital of the PLA Joint Logistics Support Force (Primary Bethune International Peace Hospital of PLA)
Shijiazhuang, Hebei, 050082, China
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Xijing Hospital of Digestive Diseases
Xi'an, Shaanxi, 710032, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Stomach lining may hold clues to pancreatitis outcomes
- Could a back injection ease the need for life support in pancreatitis?
- Cooling the pancreas from the inside: a new device aims to tame severe inflammation
- Hospital stay for mild pancreatitis questioned: home care as safe?
- Can a simple score predict pancreatitis death in seniors?