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Could an epinephrine shot prevent pancreatitis after ERCP?

NCT ID NCT07173179

Disease control Sponsor: Duzce University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study tested whether injecting epinephrine around the bile duct opening, combined with a standard rectal anti-inflammatory drug, could reduce pancreatitis after ERCP—a common procedure to treat bile duct blockages. Over 500 adults with a first-time ERCP took part. The goal was to see if the combination worked better than the anti-inflammatory drug alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
epinephrine injection and rectal indomethacin
What this could lead to
If it works, this could offer a simple, low-cost way to lower the risk of pancreatitis after a common bile duct procedure.
What could go wrong
This is a completed Phase 4 trial, but the results are not yet published. The added benefit of epinephrine injection over standard care may be small, and injection carries a slight risk of bleeding or tissue damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

504 people

The number who actually took part.

Started

Jan 2023

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria All patients with a naïve papilla that required ERCP for treatment of biliary obstruction, aged between 18 and 80. Exclusion Criteria * Pregnancy * Inability to provide written informed consent * Previous history of ERCP * Ampulla of Vater cancer * Surgically altered anatomy

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Conditions

The condition(s) this trial relates to.

acute pancreatitis cholestasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post-ercp acute pancreatitis

Contacts and locations

Locations

  • Duzce University School of Medicine

    Düzce, 81620, Turkey (Türkiye)

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