New synthetic skin patch tested for Hard-to-Heal wounds

NCT ID NCT04927702

Terminated Disease control Sponsor: Acera Surgical, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a man-made skin substitute called Restrata for treating diabetic foot ulcers and venous leg ulcers. For diabetic foot ulcers, Restrata was compared to standard wound care. For venous leg ulcers, it was compared to a living cell-based skin substitute (Apligraf). The goal was to see if Restrata could help wounds close completely. The trial was terminated early and involved 48 participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Synthetic Hybrid-Scale Fiber Matrix (Restrata)
What this could lead to: If successful, this could provide a new, off-the-shelf option for closing chronic wounds like diabetic foot ulcers and venous leg ulcers, potentially reducing healing time.
What could go wrong: The trial was terminated early with only 48 participants, so results are limited. Synthetic skin substitutes may not work as well as living cell-based treatments for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Diabetic Foot ulcer of lower limbs Varicose Ulcer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC FOOT ULCER VENOUS LEG ULCER

Contacts and locations

Locations

Barry University

Miami Beach, Florida, 33169, United States
Boston Medical Center

Boston, Massachusetts, 02118, United States
Gundersen Health System

La Crosse, Wisconsin, 54601, United States
ILD Research Center

Vista, California, 92083, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
University of Florida - Jacksonville

Jacksonville, Florida, 32209, United States

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