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Experimental liver drug shows early promise but trial cut short

NCT ID NCT05900050

Terminated Disease control Sponsor: Genfit Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 24, 2026 · Updated 3 times

Summary

This early study tested a drug called VS-01 in 15 adults with acute-on-chronic liver failure (a sudden worsening of liver function) and fluid buildup in the belly. Participants received either VS-01 plus standard care or standard care alone. The trial was terminated early, so we have limited data on whether VS-01 helps improve survival or liver function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
VS-01 (a liposomal drug given into the abdominal cavity)
What this could lead to
If successful, VS-01 could offer a new way to manage acute-on-chronic liver failure and reduce short-term mortality.
What could go wrong
This is a very early, small study (15 people) that was terminated, so results are limited. The drug is experimental and may not improve outcomes or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Acute-On-Chronic Liver Failure Ascites Fibrosis kidney disorder kidney failure liver disorder liver failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE-ON-CHRONIC LIVER FAILURE ASCITES

Contacts and locations

Locations

  • ASST Grande Ospedale Metropolitano Niguarda

    Milan, 20162, Italy

  • Azienda Ospedaliero-Universitaria Policlinico Umberto I

    Roma, 00185, Italy

  • Baylor Clinic

    Houston, Texas, 77030, United States

  • CHU Rennes - Hôpital Pontchaillou

    Rennes, 35033, France

  • Centre Hospitalier Régional Universitaire de Tours

    Chambray-lès-Tours, 37170, France

  • Charité Universitätsmedizin Berlin

    Berlin, State of Berlin, 13353, Germany

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Columbia University Medical Center/ New York Presbyterian Hospital

    New York, New York, 10032, United States

  • Debreceni Egyetem Klinikai Központ

    Debrecen, 4032, Hungary

  • Heves Vármegyei Markhot Ferenc Oktatókórház és Rendelőintézet

    Eger, 3300, Hungary

  • Hospital Clínic de Barcelona

    Barcelona, Barcelona, 08036, Spain

  • Hôpital Universitaire Pitié Salpêtrière

    Paris, 75013, France

  • Hôpital de la Croix Rousse

    Lyon, 69004, France

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Medizinische Hochschule Hannover

    Hanover, 30625, Germany

  • Medstar Georgetown University Hospital

    Washington D.C., District of Columbia, 20007, United States

  • Piedmont Atlanta Hospital

    Atlanta, Georgia, 30309, United States

  • Richmond VA Medical Center

    Richmond, Virginia, 23249, United States

  • Tampa General Hospital

    Tampa, Florida, 33606, United States

  • The Liver Institute at Methodist Dallas

    Dallas, Texas, 75203, United States

  • Universitair Ziekenhuis Antwerpen

    Edegem, 2650, Belgium

  • Universitatsklinikum Munster

    Münster, North Rhine-Westphalia, 48149, Germany

  • University of California Davis Medical Center

    Sacramento, California, 95817, United States

  • University of Missouri Health Care

    Columbia, Missouri, 65212, United States

  • Virginia Commonwealth University

    Richmond, Virginia, 23298, United States

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