Experimental liver drug shows early promise but trial cut short

NCT ID NCT05900050

Terminated Disease control Sponsor: Genfit Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early study tested a drug called VS-01 in 15 adults with acute-on-chronic liver failure (a sudden worsening of liver function) and fluid buildup in the belly. Participants received either VS-01 plus standard care or standard care alone. The trial was terminated early, so we have limited data on whether VS-01 helps improve survival or liver function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

VS-01 (a liposomal drug given into the abdominal cavity)

What this could lead to

If successful, VS-01 could offer a new way to manage acute-on-chronic liver failure and reduce short-term mortality.

What could go wrong

This is a very early, small study (15 people) that was terminated, so results are limited. The drug is experimental and may not improve outcomes or could cause side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Acute-On-Chronic Liver Failure Ascites Fibrosis kidney disorder kidney failure liver disorder liver failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE-ON-CHRONIC LIVER FAILURE ASCITES

Contacts and locations

Show contact details

Locations

ASST Grande Ospedale Metropolitano Niguarda

Milan, 20162, Italy
Azienda Ospedaliero-Universitaria Policlinico Umberto I

Roma, 00185, Italy
Baylor Clinic

Houston, Texas, 77030, United States
CHU Rennes - Hôpital Pontchaillou

Rennes, 35033, France
Centre Hospitalier Régional Universitaire de Tours

Chambray-lès-Tours, 37170, France
Charité Universitätsmedizin Berlin

Berlin, State of Berlin, 13353, Germany
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Columbia University Medical Center/ New York Presbyterian Hospital

New York, New York, 10032, United States
Debreceni Egyetem Klinikai Központ

Debrecen, 4032, Hungary
Heves Vármegyei Markhot Ferenc Oktatókórház és Rendelőintézet

Eger, 3300, Hungary
Hospital Clínic de Barcelona

Barcelona, Barcelona, 08036, Spain
Hôpital Universitaire Pitié Salpêtrière

Paris, 75013, France
Hôpital de la Croix Rousse

Lyon, 69004, France
Mayo Clinic

Rochester, Minnesota, 55905, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Medizinische Hochschule Hannover

Hanover, 30625, Germany
Medstar Georgetown University Hospital

Washington D.C., District of Columbia, 20007, United States
Piedmont Atlanta Hospital

Atlanta, Georgia, 30309, United States
Richmond VA Medical Center

Richmond, Virginia, 23249, United States
Tampa General Hospital

Tampa, Florida, 33606, United States
The Liver Institute at Methodist Dallas

Dallas, Texas, 75203, United States
Universitair Ziekenhuis Antwerpen

Edegem, 2650, Belgium
Universitatsklinikum Munster

Münster, North Rhine-Westphalia, 48149, Germany
University of California Davis Medical Center

Sacramento, California, 95817, United States
University of Missouri Health Care

Columbia, Missouri, 65212, United States
Virginia Commonwealth University

Richmond, Virginia, 23298, United States