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Can a Two-Probe technique double the pain relief for knee arthritis?

NCT ID NCT07789340

Symptom relief Sponsor: Tanta University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 27, 2026 · Last updated Sep 02, 2026 · Updated 3 times

Summary

This trial tests whether using two probes during radiofrequency ablation eases knee osteoarthritis pain better than the standard one-probe approach. Radiofrequency ablation uses heat to quiet the nerves that send pain signals from the knee. Researchers will enroll 64 adults over 50 with chronic knee pain that has not improved with other treatments. Participants will receive either unipolar or bipolar ablation, and the team will track pain levels and knee function for 24 weeks to see which method provides more relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Radiofrequency ablation of knee nerves, using either one cannula (unipolar) or two cannulas (bipolar)
What this could lead to
If one technique proves better, it could offer a more effective, longer-lasting pain relief option for people with knee osteoarthritis who have not responded to other treatments.
What could go wrong
This is a small, early-stage trial with 64 participants, so results may not apply to everyone. The procedure carries typical risks of nerve ablation, such as temporary numbness or increased pain, and the benefit may fade over time.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 64 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 50 years. * Both genders. * Diagnosed with chronic knee osteoarthritis (KOA) according to the American College of Rheumatology (ACR) criteria and confirmed with plain radiography as the gold standard for the diagnosis of KOA. * One chronic KOA pain not responding to other treatments as physiotherapy, oral analgesics, and intraarticular injection with hyaluronic acids or steroids. * Kellgren-Lawrence grade (II-IV). Exclusion Criteria: * Chronic knee pain induced by infection, inflammation, tumors, and fractures. * Prior knee surgery. * Acute knee pain. * Connective tissue diseases. * Neurologic or psychiatric disorders. * Intra-articular knee corticosteroid or hyaluronic acids in the past 3 months. * Anticoagulant medication. * Local infection of the site of intervention. * Cognitive impairment.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bipolar radiofrequency ablation Knee osteoarthritis Pain Unipolar radiofrequency ablation

How to take part

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  1. The places running it

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  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Tanta University

    RECRUITING

    Tanta, El-Gharbia, 31527, Egypt

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