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Can adding dextrose or saline boost pain injection relief?

NCT ID NCT07771374

Symptom relief Sponsor: Gaziler Physical Medicine and Rehabilitation Education and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 18, 2026 · Last updated Aug 20, 2026 · Updated 2 times

Summary

This trial tests whether adding dextrose or saline to a standard lidocaine and dexamethasone injection improves pain relief and function in people with chronic leg and back pain from a single-level lumbar disc herniation. Participants receive an ultrasound-guided injection around the affected nerve root, with or without the extra ingredients. The study measures pain, disability, quality of life, and painkiller use before and up to three months after the injection.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Lidocaine and dexamethasone injection, with or without dextrose or saline
What this could lead to
If adding dextrose or saline improves outcomes, it could lead to a more effective, minimally invasive treatment for chronic leg and back pain from disc herniation.
What could go wrong
This is a small, early-stage trial, and the added benefit of dextrose or saline may be minimal. Injections carry risks like infection, bleeding, or nerve damage, though rare.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

33 people

The number who actually took part.

Started

May 2025

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 25 and 65 years * Persistent low back and leg pain despite conservative treatment * Unilateral radicular pain accompanying chronic low back pain lasting longer than 3 months * Single-level lumbar disc herniation (LDH) confirmed by clinical evaluation and magnetic resonance imaging (MRI) * Low back pain and unilateral radicular leg pain with a Visual Analog Scale (VAS) score ≥4 * Provision of written informed consent to participate in the study Exclusion Criteria: * Lumbar epidural steroid injection within the previous 6 months or a history of major trauma * History of allergy to any of the medications to be administered * Body mass index (BMI) \>30 kg/m² * Unstable chronic medical disease, such as diabetes mellitus, hypertension, or heart failure * History of lumbar spine surgery * History of coagulopathy * History of malignancy * History of polyneuropathy * History of peripheral vascular disease * Presence of a psychiatric disorder or cognitive impairment that would prevent completion of questionnaires and assessment scales, including dementia or significant visual or hearing impairment * Local infection at the injection site or systemic infection * Pregnancy and/or breastfeeding * Neurological deficit in the lower extremities * Unwillingness to participate in the study

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Conditions

The condition(s) this trial relates to.

Intervertebral Disc Displacement radiculopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lumbar disc herniation with radiculopathy

Contacts and locations

Locations

  • Gaziler Physical Medicine and Rehabilitation Training and Research Hospital

    Ankara, Ankara, 06800, Turkey (Türkiye)

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