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Can a gel or nanoparticles tame tooth pain after pulp treatment?

NCT ID NCT07774130

Symptom relief Sponsor: Future University in Egypt Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time

Summary

This trial tests whether using sodium hypochlorite as a gel or solution, with or without tiny nanoparticles, affects pain after a pulpotomy—a procedure that removes the inflamed pulp inside a tooth. Adults aged 15 to 40 with severe pulpitis in a lower molar will be randomly assigned to one of four groups. Pain will be tracked for a week, and the success of the treatment will be checked over a year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Sodium hypochlorite 2% gel or solution, with or without chitosan nanoparticles, used as a haemostatic agent during pulpotomy
What this could lead to
If one form works better, it could point to a more comfortable dental procedure for people with severe tooth pain.
What could go wrong
This is a small, early-stage trial, and the results may not apply to everyone. There is also a risk of tissue irritation from the chemicals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Mar 2026

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • Patients suffering from Symptomatic irreversible pulpitis in mature mandibular molars. * Patients of either gender aged from 15-40. * Patients free from any systemic disease that may affect normal healing and predictable outcome. * Patients who will agree to the consent and will commit to follow-up period. * Patients with mature root. * Patients with no internal or external resorption and no periapical lesions. * Tooth give positive response to sensitivity test. * Tooth is restorable and free from advanced periodontal disease, cracks and splits. * Hemostasis achieved after total pulpotomy. * Soft tissues around the tooth are normal with no swelling or sinus tract. Exclusion Criteria: * • Hemostasis after 10 minutes can not be controlled after total pulpotomy. * Patients with immature roots. * Patients with any systemic disease that may affect normal healing. * Patients with periapical lesions or infections. * Pregnant females. * Patients who could/would not participate in a 6 months follow-up. * Patients with fistula or swelling * Patients with necrotic pulp. * Patients with old age.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Irriversible pulpitis Postoperative pain Pulpotomy Vital pulp therapies

Contacts and locations

Locations

  • University

    Cairo, 11511, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.