Promising drug targets severe weight gain from brain damage
NCT ID NCT06760546
First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 28 times
Summary
This study tests a daily injection called setmelanotide to help people aged 4 and older who have severe obesity due to a brain condition (hypothalamic obesity). Participants receive either the drug or a placebo for 26 weeks. The goal is to see if it reduces weight, hunger, and improves quality of life.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Birmingham Women and Children's Hospital NHS Trust
RECRUITINGBirmingham, West Midlands, B46NH, United Kingdom
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Boston Children's Hospital
RECRUITINGBoston, Massachusetts, 02115, United States
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Children's Hospital Colorado
RECRUITINGAurora, Colorado, 80045, United States
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Children's Minnesota
RECRUITINGSaint Paul, Minnesota, 55102, United States
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Columbia University Irving Medical Center
RECRUITINGNew York, New York, 10032, United States
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Hull Royal Infirmary
RECRUITINGHull, HU32RW, United Kingdom
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Lurie Children's Hospital
RECRUITINGChicago, Illinois, 60611, United States
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Seattle Children's Research Institute
RECRUITINGSeattle, Washington, 98105, United States
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UCL Great Ormond Street Institute of Child Health
RECRUITINGLondon, Greater London, WC1N 1EH, United Kingdom
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University of Alabama
RECRUITINGBirmingham, Alabama, 35233, United States
Conditions
Explore the condition pages connected to this study.