New pill targets hard-to-treat obesity after brain injury
NCT ID NCT06046443
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested an experimental daily pill, LB54640, in 28 people aged 12 and older with hypothalamic obesity—a condition where brain injury causes rapid, severe weight gain. For the first 14 weeks, some received the drug and some a placebo to see if it safely reduces weight and hunger. Those who finished could continue on the drug for up to a year.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Birmingham Women's and Children's NHS Foundation Trust
Birmingham, B15 2TG, United Kingdom
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Columbia University
New York, New York, 10027, United States
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Great Ormond Street Hospital for Children
London, WC1N 3JH, United Kingdom
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Lynn Health Science Institute
Oklahoma City, Oklahoma, 73112, United States
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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The University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27514, United States
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Tufts Medical Center
Boston, Massachusetts, 02111, United States
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University of Cambridge
Cambridge, CB2 1TN, United Kingdom
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University of Iowa Children's Hospital
Iowa City, Iowa, 52242, United States