Bladder cancer patients who Can't take chemo may get new option
NCT ID NCT05241340
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial tests a combination of an immunotherapy drug called sasanlimab and focused radiation given before bladder removal surgery in 33 patients with muscle-invasive bladder cancer who cannot take standard chemotherapy. The goal is to see if this approach is safe, feasible, and can eliminate cancer in the bladder at the time of surgery. The study is active but no longer recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Sasanlimab (an immunotherapy drug) and stereotactic body radiation therapy (focused radiation)
- What this could lead to
- If successful, this combination could offer a new treatment option for bladder cancer patients who cannot receive standard chemotherapy, potentially improving outcomes before surgery.
- What could go wrong
- This is a small, early-phase trial with only 33 participants, so results may not apply to everyone. The treatment also carries risks of side effects from both immunotherapy and radiation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Houston Methodist Hospital
Houston, Texas, 77006, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can Pre-Surgery chemotherapy outsmart aggressive bladder cancer?
- Bladder cancer: a new combo aims to avoid radical surgery
- Can a special PET scan see bladder cancer more clearly?
- Bladder cancer surgery: what happens after the bladder is removed?
- Can a Bladder-Instilled biologic keep recurrent bladder cancer at bay?
- Lab-Grown tumor clusters guide tailored bladder cancer therapy