Which drug makes intubation safer? major trial tests remifentanil vs rocuronium

NCT ID NCT06564857

Recruiting now Knowledge-focused Sponsor: Nordsjaellands Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial compares two drugs—remifentanil (a strong painkiller) and rocuronium (a muscle relaxant)—for placing a breathing tube during surgery using a video laryngoscope. About 2,648 adults undergoing general anesthesia will be randomly assigned to one drug. The goal is to see which causes fewer complications like low oxygen, heart issues, or failed first attempts at tube placement. The results could help make intubation safer for millions of patients worldwide.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: remifentanil and rocuronium
What this could lead to: If it works, this could show that using remifentanil instead of rocuronium for intubation is safer and reduces complications like breathing problems or awareness during surgery.
What could go wrong: This is a large phase 4 trial, but it compares two drugs already in use, so it won't lead to a new treatment. The results may only apply to video laryngoscopy and not change standard practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for REMIFENTANIL are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

REMIFENTANIL ROCURONIUM TRACHEAL INTUBATION VIDEO LARYNGOSCOPY

Contacts and locations

Locations

Department of Anesthesiology, NOH, Rigshospitalet
RECRUITING

Copenhagen, 2100, Denmark
Department of Anesthesiology, North Zeeland Hospital
RECRUITING

Hillerød, 3400, Denmark

More trials for these conditions

Other studies related to the condition(s) this trial covers.