Which drug makes intubation safer? major trial tests remifentanil vs rocuronium
NCT ID NCT06564857
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This trial compares two drugs—remifentanil (a strong painkiller) and rocuronium (a muscle relaxant)—for placing a breathing tube during surgery using a video laryngoscope. About 2,648 adults undergoing general anesthesia will be randomly assigned to one drug. The goal is to see which causes fewer complications like low oxygen, heart issues, or failed first attempts at tube placement. The results could help make intubation safer for millions of patients worldwide.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
remifentanil and rocuronium
What this could lead to
If it works, this could show that using remifentanil instead of rocuronium for intubation is safer and reduces complications like breathing problems or awareness during surgery.
What could go wrong
This is a large phase 4 trial, but it compares two drugs already in use, so it won't lead to a new treatment. The results may only apply to video laryngoscopy and not change standard practice.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Department of Anesthesiology, NOH, Rigshospitalet
RECRUITINGCopenhagen, 2100, Denmark
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Department of Anesthesiology, North Zeeland Hospital
RECRUITINGHillerød, 3400, Denmark
Contact Phone: •••-•••-•••• Email: •••••@•••••