A new blood marker may outperform lactate in predicting septic shock survival
NCT ID NCT05327881
First seen Aug 21, 2026 · Last updated Aug 21, 2026
Summary
This study asks whether changes in blood renin levels over the first 72 hours can predict death in septic shock patients better than the standard lactate test. Researchers will measure renin and lactate at enrollment and at 24, 48, and 72 hours in 60 adults with septic shock. The goal is to see which marker more accurately forecasts 28-day mortality, which could guide future treatment decisions.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Blood tests measuring plasma renin and lactate levels
- What this could lead to
- If renin changes prove better than lactate at predicting death, doctors could use it to identify high-risk septic shock patients earlier and tailor treatment.
- What could go wrong
- This is a small, single-center study with 60 patients, so results may not apply broadly. Renin testing is not yet standard and could be less practical in routine care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
60 people
The number who actually took part.
- Started
-
Jan 2025
- Finished
-
Jun 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Septic shock patients, septic shock was defined as persistent hypotension (defined as the need for vasopressors to maintain mean arterial pressure ≥ 65 mm Hg, and a serum lactate level \> 18 mg/dL \[2 mmol/L\] despite adequate volume resuscitation
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
adult patients aged 18 years or older who were diagnosed with septic shock according to the Third International Consensus Definitions for Sepsis and Septic Shock.\[1\] In septic shock, patients' blood lactate levels were found to be more than 2 mmol/L even after receiving enough fluids, and patients' mean arterial pressure (MAP) had to be maintained at 65 mmHg or above with the use of vasopressor medication.Before enrollment, all patients or their authorized representatives were asked to provide written informed consent. Patients were excluded if they had acute coronary syndrome, chronic treatment with angiotensin receptor blockers (ARBs) or ACE inhibitors (ACEIs), a do-not-resuscitate (DNR) order, chronic kidney disease stage IV or V (baseline estimated glomerular filtration rate \<30 mL/min/1.73 m²), or if they passed away within the first 24 hours of being admitted to the intensive care unit (ICU).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Omar Ali
Asyut, 71515, Egypt
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Other studies related to the condition(s) this trial covers.
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