A fingertip test that could reveal hidden danger in sepsis
NCT ID NCT07774962
First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time
Summary
This study looks at whether a simple bedside check called capillary refill time (pressing on a fingernail to see how fast color returns) can be combined with a blood test to spot a hidden problem in septic shock. Sometimes blood flow to organs seems normal, but tissues are still not getting enough oxygen. The study will follow 100 adults with septic shock, measuring these two markers at several time points, to see if a mismatch between them is linked to higher risk of death within 28 days. No extra procedures are involved—all measurements are part of routine care.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Capillary refill time measurement and oxygen extraction ratio calculation from routine blood gases
- What this could lead to
- If this works, it could help doctors identify septic shock patients who need more tailored treatment, potentially improving survival.
- What could go wrong
- This is a small, single-center observational study, so it can only show associations, not cause and effect. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
-
Aug 2026
An estimate. Start dates often move.
- Expected to finish
-
Jul 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Consecutive adult patients (≥18 years) admitted to a single-center intensive care unit and diagnosed with septic shock according to the Surviving Sepsis Campaign (SSC) 2026 guideline, who already have a central venous catheter and an arterial line in place as part of their clinical care. Patients are enrolled from all admission sources (emergency department, ward, operating room, or external referral) and followed prospectively while receiving standard treatment. Patients with active bleeding, ongoing ECMO, conditions that make capillary refill time measurement unreliable (e.g., Raynaud phenomenon or significant peripheral vascular disease), death within the first 6 hours, or inability to obtain hour-6 CRT or blood gas measurements are not included.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 years * Diagnosis of septic shock according to the Surviving Sepsis Campaign (SSC) 2026 guideline * Presence of both a central venous catheter and an arterial line Exclusion Criteria: * Active bleeding * Ongoing extracorporeal membrane oxygenation (ECMO) * Raynaud phenomenon or significant peripheral vascular disease that makes capillary refill time measurement unreliable (e.g., critical ischemia, amputation, digital ulcer/necrosis, or inability to measure on the right index finger) * Death within the first 6 hours * Inability to obtain hour-6 CRT or blood gas (phenotyping not possible)
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Sepsis are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Basaksehir Cam and Sakura City Hospital
RECRUITINGIstanbul, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Persistent inflammation, immunosuppression and catabolism syndrome (PICS): a new horizon for surgical critical care subtitle: cardiac dysfunction in older sepsis survivors subtitle: development of a designer Proline-Rich antimicrobial peptide chaperone protein inhibitor (DPC) for treating sepsis
- A randomized clinical trial of early empiric Anti-Mycobacterium tuberculosis therapy for sepsis in Sub-Saharan africa
- Tracing of real-time glu13Cose metabolism in human immune cells - intensive care unit
- Can a blood filter strip away toxins in septic shock?
- Could a neck vein check replace a harder ultrasound for ICU fluid management?
- Sepsis alert system aims to speed up critical care response in hospitals