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Can 3D ultrasound reveal how ICU muscles recover?

NCT ID NCT07069959

Knowledge-focused Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 01, 2026 · Last updated Sep 02, 2026 · Updated 1 time

Summary

This study follows 100 intensive care patients on ventilators to see how their thigh muscles recover. Researchers use a handheld strength tester and 3D ultrasound to measure muscle size and strength over time. The goal is to find better ways to predict and track recovery from ICU-acquired weakness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Non-invasive muscle strength assessments using manual dynamometry and 3D ultrasound
What this could lead to
If successful, this could lead to better tools for predicting and tracking muscle recovery in ICU patients, potentially improving rehabilitation strategies.
What could go wrong
This is an observational study, so it won't test a treatment. The measurements may not perfectly predict long-term recovery, and results may not apply to all ICU patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population includes adults (aged \>18 years) admitted to the ICU and treated with invasive mechanical ventilation for at least 4 days. Participants must be conscious, cooperative, and have an MRC score ≥ 3/5 for "Leg Extension" on either side. Informed consent or no objection is required. Exclusion criteria include pregnancy, neurological disorders, lower limb injuries, or conditions preventing safe participation.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged \> 18 years * Hospitalized in an ICU * Treated with invasive mechanical ventilation (MV) for at least 4 days during their stay (may be extubated at the time of inclusion) * Conscious and cooperative patients: ability to respond appropriately to the following commands: open and close eyes, look at me, nod your head, stick out your tongue, raise your eyebrows when I count to five * MRC score ≥ 3/5 for the "Leg Extension" function on either the left or right side * Informed consent obtained (no opposition) Exclusion Criteria: * Pregnant or breastfeeding women * Fracture or amputation of a lower limb * Acute or chronic brain or spinal cord injury responsible for hemiplegia or paraplegia * Unstable spinal injury * Neurodegenerative or chronic neurological disease * Guillain-Barré Syndrome * Myasthenia Gravis * Acute deep vein thrombosis of the lower limbs treated within the last 48 hours * Pre-existing motor deficit in a lower limb before the ICU stay, of any cause * Incarcerated or legally protected individuals (guardianship, curatorship) * Individuals without social protection

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Conditions

The condition(s) this trial relates to.

critical illness polyneuropathy Muscle Weakness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intensive care unit acquired weakness Muscle weakness

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Nantes University Hospital

    RECRUITING

    Nantes, Loire Atlantique, 44300, France

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