Targeted drug trial aims to outperform chemo for tough lung cancer

NCT ID NCT04222972

Summary

This study compared a new targeted drug called pralsetinib against standard chemotherapy for people with advanced lung cancer that has spread and carries a specific genetic change called a RET fusion. The trial involved 223 participants worldwide who had not yet received treatment for their advanced cancer. Researchers measured whether the targeted drug could help patients live longer without their cancer getting worse compared to chemotherapy.

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Contacts and locations

Locations

  • ?zmir Medical Point

    Kar?iyaka, 35575, Turkey (Türkiye)

  • A.O.U. INTEGRATA DI VERONA-Ospedale Civile Maggiore Borgo Trento

    Verona, Veneto, 37126, Italy

  • AZ. Ospedaliera San Giovanni - Addolorata

    Rome, Lazio, 00184, Italy

  • Adana City Hospital, Medical Oncology

    Adana, 01060, Turkey (Türkiye)

  • Ankara Bilkent City Hospital

    Ankara, 06490, Turkey (Türkiye)

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Asklepios-Fachkliniken Muenchen-Gauting

    Gauting, 82131, Germany

  • Azienda Ospedaliera Universitaria Pisana - Ospedale Cisanello

    Pisa, Tuscany, 56124, Italy

  • CHRU Lille Service de Pneumologie et Oncologie Thoracique

    Lille, 59000, France

  • CHU Strasbourg - Nouvel Hopital Civil

    Strasbourg, 67091, France

  • CHU de Toulouse - Hôpital Larrey

    Toulouse, 31100, France

  • Centro Oncologico Riojano Integral (CORI)

    La Rioja, F5300COE, Argentina

  • Christie Hospital Nhs Trust

    Manchester, M2O 4BX, United Kingdom

  • Clinica CIMCA

    San José, 10103, Costa Rica

  • Complejo Hospitalario Universitario A Coruña

    A Coruña, LA Coruna, 15006, Spain

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, Lombardy, 20133, Italy

  • Guys & St Thomas Hospital

    London, SE1 9RT, United Kingdom

  • Health Pharma Professional Research

    Mexico City, Mexico CITY (federal District), 03100, Mexico

  • Hemato Oncología de Panamá Especializada

    Panama City, 0801, Panama

  • Hopital Bichat Claude Bernard

    Paris, 75018, France

  • Hopital Tenon

    Paris, 75970, France

  • Hopital de Pontchaillou

    Rennes, 35033, France

  • Hosp Clinico Univ Lozano Blesa

    Zaragoza, 50009, Spain

  • Hospital A. C. Camargo

    São Paulo, São Paulo, 01509-010, Brazil

  • Hospital Britanico

    Buenos Aires, C1280AEB, Argentina

  • Hospital General Universitario Gregorio Marañon

    Madrid, 28007, Spain

  • Hospital Ramon y Cajal

    Madrid, 28034, Spain

  • Hospital Regional Universitario de Malaga

    Málaga, 29010, Spain

  • Hospital Sao Lucas - PUCRS

    Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital Universitario Marques de Valdecilla

    Santander, Cantabria, 39008, Spain

  • Hospital de Madrid Norte Sanchinarro- Centro Integral Oncologico Clara Campal

    Madrid, 28050, Spain

  • Hôpital Ambroise Paré - Boulogne-Billancourt

    Boulogne-Billancourt, 92100, France

  • Hôpital Louis Pradel, Hospices Civils de Lyon

    Bron, 69677, France

  • IOV - Istituto Oncologico Veneto - IRCCS

    Padua, Veneto, 35128, Italy

  • IPO do Porto

    Porto, 4200-072, Portugal

  • IRCCS Giovanni Paolo II Istituto Oncologico

    Bari, Apulia, 70124, Italy

  • Ico Rene Gauducheau

    Saint-Herblain, 44805, France

  • Insititut Catala D'Oncologia

    L'Hospitalet de Llobregat, Barcelona, 08908, Spain

  • Institut Bergonie CLCC Bordeaux

    Bordeaux, 33000, France

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Institut Paoli Calmettes

    Marseille, 13273, France

  • Irccs Ospedale San Raffaele

    Milan, Lombardy, 20132, Italy

  • Istituto Europeo Di Oncologia

    Milan, Lombardy, 20141, Italy

  • Istituto Nazionale Tumori Regina Elena

    Rome, Lazio, 00144, Italy

  • Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione G. Pascale

    Naples, Campania, 80131, Italy

  • Juntendo University Hospital

    Tokyo, 113-8431, Japan

  • Kansai Medical University Hospital

    Osaka, 573-1191, Japan

  • Karolinska Universitetssjukhuset, Solna

    Stockholm, 171 76, Sweden

  • Klinik Schillerhöhe

    Stuttgart, 70376, Germany

  • Kyushu University Hospital

    Fukuoka, 812-8582, Japan

  • Leicester Royal Infirmary

    Leicester, LE1 5WW, United Kingdom

  • Leopoldina-Krankenhaus Medizinische Klinik II

    Schweinfurt, 97422, Germany

  • Maastricht University Medical Center

    Maastricht, 6229 HX, Netherlands

  • NKI/AvL

    Amsterdam, 1066 CX, Netherlands

  • Narod.Inst.Onkol. im. M.Sklodowskiej - Curie-Panst.Inst.Bad

    Warsaw, 02-781, Poland

  • National Cancer Center

    Goyang-si, 10408, South Korea

  • National Hospital Organization Himeji Medical Center

    Hyōgo, 670-8520, Japan

  • National Hospital Organization Yamaguchi - Ube Medical Center

    Yamaguchi, 755-0241, Japan

  • Osaka International Cancer Institute

    Osaka, 541-8567, Japan

  • Oslo universitetssykehus HF, Ullevål, Kreftsenteret

    Oslo, 0450, Norway

  • Ospedale Clinicizzato SS Annunziata

    Chieti, Abruzzo, 66100, Italy

  • Ospedale Provinciale Santa Maria Delle Croci

    Ravenna, Emilia-Romagna, 48100, Italy

  • Pius-Hospital

    Oldenburg, 26121, Germany

  • Royal Marsden Hospital

    London, SW3 6JJ, United Kingdom

  • Royal North Shore Hospital

    St Leonards, New South Wales, 2065, Australia

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital, Yonsei University Health System

    Seoul, 03722, South Korea

  • St. James Hospital

    Dublin, D08 HNY1, Ireland

  • The Cancer Institute Hospital of JFCR

    Tokyo, 135-8550, Japan

  • UZ Antwerpen

    Edegem, 2650, Belgium

  • UniversitätsSpital Zürich

    Zurich, 8091, Switzerland

  • Universitätsklinikum Carl Gustav Carus, Medizinische Klinik I, Pneumologie MK1-A13

    Dresden, 01307, Germany

  • Velindre Cancer Centre

    Cardiff, CF14 2TL, United Kingdom

Conditions

Explore the condition pages connected to this study.