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Practice quitting: a new way to help smokers who Aren't ready to stop?

NCT ID NCT05513872

Symptom relief Sponsor: Rush University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 09, 2026 · Last updated Sep 10, 2026 · Updated 1 time

Summary

Many smokers are not ready to set a quit date, so traditional cessation programs miss them. This trial tests whether counseling focused on practice quitting, where smokers try not smoking for short periods without pressure to quit forever, helps them make a real quit attempt later. Researchers also test whether giving a four-week supply of nicotine patches and lozenges encourages practice quitting. The study enrolls 780 daily smokers who are not planning to quit in the next month but are open to changing their smoking in the next six months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Nicotine replacement therapy (patches and lozenges) plus practice quitting counseling
What this could lead to
If it works, this could give smokers who are not ready to quit a low-pressure way to build skills and confidence, leading to more successful quit attempts later.
What could go wrong
Practice quitting may not translate into lasting abstinence, and nicotine replacement carries known side effects like skin irritation or nausea. The trial tests a behavioral approach, so results may depend on how well participants stick with the counseling.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 780 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2023

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Eligible participants will be males and females who: 1. are 18 years or older 2. report current daily cigarette smoking (≥ 5 cigarettes per day) 3. are not planning to quit in the next 30 days 4. are not currently engaged in smoking cessation treatment 5. are motivated to quit or engage in a non-cessation goal (i.e., reduce smoking, learn more about treatment options, and/ or try out skills to change smoking) in the next 6 months 6. are English speaking 7. reside in the continental United States 8. have access to a smartphone that can be used to complete study procedures Exclusion Criteria: Participants will be excluded for daily vaping/ electronic cigarettes use (i.e., use for ≥ 25 days within past 30 days) and any FDA contraindications for NRT use if they: 1. are pregnant/breastfeeding 2. had recent cardiovascular trauma such as myocardial infarction 3. had a stroke within the past 3 months

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Conditions

The condition(s) this trial relates to.

nicotine dependence Smoking Smoking Cessation Tobacco Use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nicotine dependence Nicotine withdrawal Smoking behaviors Smoking cessation Tobacco use

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Rush University Medical Center

    RECRUITING

    Chicago, Illinois, 60612, United States

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