New drug cocktail targets Hard-to-Treat HER2 cancers

NCT ID NCT07137416

First seen Jan 06, 2026 · Last updated May 22, 2026 · Updated 24 times

Summary

This early-stage trial tests the safety and best dose of combining two drugs—pidnarulex and trastuzumab deruxtecan—in people with advanced breast cancer or other solid tumors that have a protein called HER2. The study includes up to 36 adults whose cancer has spread, cannot be removed by surgery, or no longer responds to standard treatments. The goal is to find a dose that is safe and may help control the disease.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Dana-Farber - Harvard Cancer Center LAO

    RECRUITING

    Boston, Massachusetts, 02115, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

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