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Mind-Body exercise may rewire how knees handle pain

NCT ID NCT05730829

Symptom relief Sponsor: McMaster University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 28, 2026 · Last updated Aug 28, 2026

Summary

This trial compares two 8-week group exercise programs for people with knee osteoarthritis. One program combines standard neuromuscular exercise with mind-body techniques like breath regulation, relaxation, and mindfulness, plus pain neuroscience education. The other uses standard exercise with general osteoarthritis education. Researchers want to see if the pain informed approach is feasible and whether it improves pain, function, quality of life, and psychological factors.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
pain informed movement program combining neuromuscular exercise with mind-body techniques, plus pain neuroscience education
What this could lead to
If it works, this could point toward a more effective, non-drug way to manage knee osteoarthritis pain and improve daily function.
What could go wrong
This is a small pilot study focused on feasibility, not proof of effectiveness. Results may not show clear benefits, and the program requires time and commitment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

69 people

The number who actually took part.

Started

Apr 2023

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \- ≥40 years of age with diagnosis of knee osteoarthritis (OA) by a physician OR; * ≥45 years of age and having activity-related knee joint pain with or without morning stiffness lasting 30 minutes (NICE criteria) * Having an average pain intensity of 3/10 on a numeric pain scale on most days of the past month Exclusion Criteria: * Cannot communicate in English; * Has inflammatory arthritis or other systemic conditions; * Have had lower limb trauma or surgery within the past 6 months; * Have participated in a knee OA exercise program in the prior 3 months; * Have had any injection in the index knee within 3-months prior to baseline assessment * Does not have regular access to the internet * Inability to get up and down from the floor independently * Use of mobility aids * Currently participating in any other drug/device/exercise clinical trial related to OA * Planned absences (e.g., trips away) of \>1 week * Currently receiving other forms of care for knee OA pain (e.g., from a physiotherapist, chiropractor, athletic therapist, kinesiologist) * Does not meet screening for safe participation in exercise according to the Get Active questionnaire from the Canadian Society for Exercise Physiology

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis

Contacts and locations

Locations

  • McMaster University

    Hamilton, Ontario, L8S1C7, Canada

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