New pill shows promise for Hard-to-Treat kidney cancer
NCT ID NCT05119335
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested an oral drug called NKT2152 in people with advanced clear cell renal cell carcinoma that had worsened after other treatments. The goal was to find the safest dose and see if it could shrink tumors. The trial was terminated early, but the data may still help guide future research.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- NKT2152 (an oral HIF2α inhibitor)
- What this could lead to
- If successful, this could point toward a new oral treatment option for advanced kidney cancer that has stopped responding to other therapies.
- What could go wrong
- The trial was terminated early, so results are limited. It is still early-stage research, and the drug may not prove effective or safe in larger studies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Emory University
Atlanta, Georgia, 30322, United States
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HonorHealth
Scottsdale, Arizona, 85258, United States
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Indiana University Simon Comprehensive Cancer Center
Indianapolis, Indiana, 46202, United States
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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National Cancer Institute
Bethesda, Maryland, 20892-9760, United States
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Nebraska Cancer Specialists
Omaha, Nebraska, 68130, United States
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Oregon Health and Science University
Portland, Oregon, 97239, United States
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Sarah Cannon Research Institute
Denver, Colorado, 80218, United States
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Seattle Cancer Care Alliance
Seattle, Washington, 98109, United States
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UCLA
Los Angeles, California, 90095, United States
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University of Iowa
Iowa City, Iowa, 52242, United States
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University of Oklahoma
Oklahoma City, Oklahoma, 73117, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can we predict who needs extra therapy after kidney cancer surgery?
- Can a pill rewrite the genetic story of resistant kidney cancer?
- Can a new MRI scan reveal hidden tumor weaknesses?
- Can a Two-Pronged immune attack shrink kidney tumors before surgery?
- AI crystal ball for hospital wards: can software forecast oxygen drops 24 hours early?
- Can a pill boost the immune system to fight Hard-to-Treat cancers?