Mesothelioma drug trial halted early – what we know

NCT ID NCT02863055

Terminated Disease control Sponsor: European Organisation for Research and Treatment of Cancer - EORTC Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 2 trial tested whether the drug nintedanib could help people with malignant pleural mesothelioma keep their cancer from growing after initial chemotherapy. 37 patients were randomly assigned to receive either nintedanib or a placebo twice daily. The study was terminated early, so its findings are limited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nintedanib
What this could lead to: If successful, nintedanib could offer a way to delay cancer progression in mesothelioma patients after initial chemotherapy.
What could go wrong: This was a small, early-phase trial that was terminated, so results are limited. Nintedanib may not improve outcomes and can cause side effects like diarrhea or liver issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

malignant pleural mesothelioma Mesothelioma, Malignant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MALIGNANT PLEURAL MESOTHELIOMA

Contacts and locations

Locations

Manchester University NHS Foundation Trust - UHSM-Wythenshawe Hospital

Wythenshawe, Manchester, M23 9LT, United Kingdom
NHS South Tyneside-South Tyneside District Hospital

South Shields, United Kingdom
Ospedale San Paolo

Milan, Italy
Royal Marsden Hospital

Chelsea, United Kingdom
Royal Marsden Hospital

Sutton, United Kingdom
Royal Marsden Hospital - Kingston

Kingston, United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust - Weston Park Hospital

Sheffield, United Kingdom
UZ Antwerpen

Antwerp, Belgium
UZ Gent

Ghent, Belgium

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