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Could a simple drug combo cut morphine use after colon surgery?

NCT ID NCT03619538

Symptom relief Sponsor: Centre Hospitalier Universitaire de Nīmes Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether adding the drug nefopam to standard pain relief (morphine and paracetamol) can reduce the amount of morphine needed after major colon surgery. 80 adults having planned surgery for colon cancer or diverticulosis took part. The main goal was to measure total morphine use after the operation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

80 people

The number who actually took part.

Started

Jun 2007

Finished

Jun 2007

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patient with a score ASA between I and III * Patient scheduled for elective major abdominal surgery (by laparotomy) for cancer or diverticulosis * Patient that signed the consent form Exclusion Criteria: * \- Patient treated in emergency situation * Patient with chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis) * Patient that needs a surgery for restoration of continuity * Patient pregnant, breastfeeding, or during periods of genital activity using no contraception. * Patient with contraindications to nefopam, morphine, or paracetamol * Patient with chronic obstructive pulmonary disease, renal or severe hepatic impairment * Patient under analgesics treatment * Patient who participated in a clinical study in the previous 6 months.

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Conditions

The condition(s) this trial relates to.

colonic neoplasm Diverticulosis, Colonic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colonic neoplasms Diverticulosis, colonic

Contacts and locations

Locations

  • CHU de Nîmes

    Nîmes, Gard, 30029, France

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