Could a sleep hormone tame bipolar mood swings?

NCT ID NCT07472075

Recruiting now Disease control Sponsor: Lars Vedel Kessing Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding melatonin (a natural sleep hormone) to standard treatment can help stabilize daily mood swings in people with bipolar disorder. Two hundred adults with bipolar disorder will take either a melatonin capsule or a placebo every day for six months. Their mood stability will be tracked using a smartphone app.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Melatonin
What this could lead to: If it works, this could point toward a simple, low-cost add-on treatment to help stabilize mood in bipolar disorder.
What could go wrong: This is a mid-stage trial with 200 participants, so results may not apply to everyone. Melatonin may not improve mood stability more than a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for BIPOLAR AFFECTIVE DISORDER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Bipolar and Related Disorders bipolar disorder major affective disorder 6 mood disorder psychiatric disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR AFFECTIVE DISORDER

Contacts and locations

Locations

Mental Health Center Copenhagen, Copenhagen Affective Research Center (CADIC)
RECRUITING

Frederiksberg, 2000, Denmark

More trials for these conditions

Other studies related to the condition(s) this trial covers.