New pill could spare kids with rare bone disease from chemo

NCT ID NCT07371182

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new daily oral drug called luvometinib in children aged 0-18 with Langerhans cell histiocytosis (LCH) that affects certain bones. LCH is a rare condition where immune cells build up and can cause bone damage. The drug targets a faulty cell signal found in nearly all cases. Researchers want to see if this pill can keep the disease from coming back and improve quality of life, with fewer side effects than standard chemotherapy.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Histiocytosis, Langerhans-Cell Langerhans cell histiocytosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Affiliated Hospital of Guizhou Medical University

    RECRUITING

    Guiyang, Guizhou, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Anhui Provincial Children's Hospital

    RECRUITING

    Hefei, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Jiangxi Provincial Children's Hospital

    RECRUITING

    Nanchang, Jiangxi, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Kunming Children's Hospital

    RECRUITING

    Kunming, Yunan, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The First Affiliated Hospital of Xinjiang Medical University

    RECRUITING

    Ürümqi, Xinjiang, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The Second Affiliated Hospital of Anhui Medical University

    RECRUITING

    Hefei, Anhui, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The Second Affiliated Hospital of Guangxi Medical University

    RECRUITING

    Nanning, Guangxi, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • West China Second Hospital, Sichuan University

    RECRUITING

    Chengdu, Sichuan, China

    Contact Email: •••••@•••••

  • Xi'an Children's Hospital

    RECRUITING

    Xi'an, Shaanxi, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Xi'an Northwest Women's and Children's Hospital

    RECRUITING

    Xi'an, Shaanxi, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Zunyi Medical University Affiliated Hospital, Guizhou Provincial Children's Hospital

    RECRUITING

    Zunyi, Guizhou, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••