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Antibiotics alone or surgery? study tracks which endocarditis patients fare better

NCT ID NCT07825272

Knowledge-focused Sponsor: Centro Cardiologico Monzino Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Infective endocarditis is an infection of the heart's inner lining or valves. About half of patients need surgery during their hospital stay, while others receive antibiotics alone. Researchers are following 1,046 adults with confirmed endocarditis for up to 24 months to compare major health events, such as death, recurrent infection, hospitalization, and heart failure, between the two groups. The goal is to learn which patients do well without surgery and how best to monitor them long term.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the study identifies which patients fare better with antibiotics alone, it could shape follow-up guidelines and spare some people unnecessary surgery.
What could go wrong
This is an observational study, so it can show patterns but cannot prove that one treatment causes better outcomes. Patients who have surgery tend to be sicker, which can make comparisons misleading.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,046 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study will enroll approximately 1,046 patients with definite infective endocarditis across participating centers, including both retrospective and prospective cohorts. The retrospective cohort will include patients diagnosed from 2021 onward with available clinical and follow-up data. The prospective cohort will consist of consecutive patients enrolled during the study period according to routine clinical practice. Both cohorts will include patients managed surgically and patients managed with medical therapy alone. All patients will be treated according to standard clinical practice, with no additional interventions required for study participation.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All patients with definite diagnosis of endocarditis based on the modified Duke Criteria including surgical findings * Age over 18 years old Exclusion Criteria: * Exclusion criteria are cases of unconfirmed endocarditis and patients with endocarditis of PM/CIED * Patients who refuse to receive clinical follow up * Unable to give Informed Consent

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Conditions

The condition(s) this trial relates to.

endocarditis infective endocarditis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infective endocarditis (IE)

Contacts and locations

Locations

  • Centro Cardiologico Monzino; IRCCS

    Milan, Milan, 20131, Italy

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