Can a drink mix tame Immunotherapy's worst side effects in melanoma?

NCT ID NCT06880198

Recruiting now Disease control Sponsor: Fondazione Melanoma Onlus Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether a dietary supplement called Oral Impact® can lower the risk of severe side effects from immunotherapy drugs used to treat advanced melanoma. Twenty patients with inoperable locally advanced or metastatic melanoma will take the supplement for 35 days, starting a week before their first immunotherapy dose. Researchers will compare their side effect rates to historical data from similar patients who did not take the supplement.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Oral Impact® (a dietary supplement)
What this could lead to: If it works, this could point toward a way to reduce severe side effects from immunotherapy, making treatment more tolerable for melanoma patients.
What could go wrong: This is a very small, early study with only 20 people, and it compares results to historical data rather than a control group. The supplement may not reduce side effects as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cutaneous melanoma metastatic melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED MELANOMA MELANOMA METASTATIC

Contacts and locations

Locations

Istituto Nazionale Tumori IRCCS - Fondazione "G. Pascale"
RECRUITING

Naples, 80131, Italy

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