New anesthesia drug could replace propofol in surgeries
NCT ID NCT05478174
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tested whether a new drug called HSK3486 works as well as the standard drug propofol for putting adults under general anesthesia before elective surgery. About 400 participants received either HSK3486 or propofol to see if it safely and effectively induces anesthesia. The goal is to provide a reliable alternative with potentially fewer side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- HSK3486 injectable emulsion
- What this could lead to
- If successful, HSK3486 could offer a safer or more effective option for putting adults under anesthesia before surgery.
- What could go wrong
- This is a non-inferiority trial, so HSK3486 may not be better than propofol. Results are specific to elective surgeries and may not apply to emergencies or other procedures.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Arizona Research Center
Phoenix, Arizona, 85053, United States
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Brigham & Women'S Hospital
Boston, Massachusetts, 02115, United States
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Chesapeake Research Group, Llc
Pasadena, Maryland, 21122, United States
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Coastal Clinical Research Specialists
Jacksonville, Florida, 32250, United States
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Duke University Health
Durham, North Carolina, 27710, United States
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Endeavor Clinical Trials
San Antonio, Texas, 78240, United States
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ForCare Clinical Research
Tampa, Florida, 33613, United States
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Gulfcoast Research Institute, Llc
Sarasota, Florida, 34232, United States
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HD Research
Bellaire, Texas, 77401, United States
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Hd Research Llc.
Carrollton, Texas, 75006, United States
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Jbr Clinical Research
Salt Lake City, Utah, 84107, United States
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Midwest Clinical Research Center
Dayton, Ohio, 45417, United States
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NextStage Clinical Research - Abay Neuroscience Center
Wichita, Kansas, 67226, United States
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Oregon Health & Science University
Portland, Oregon, 97239, United States
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Phoenix Clinical Research
Tamarac, Florida, 33321, United States
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Rush University Medical Center
Chicago, Illinois, 60612, United States
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Shoals Medical Trials, Inc.
Sheffield, Alabama, 35660, United States
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The Ohio State University Wexner Medical Center
Columbus, Ohio, 43210, United States
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The University of Texas - MD Anderson Cancer Center
Houston, Texas, 77030, United States
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UC Davis Health
Davis, California, 95616, United States
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University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106, United States
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University of Miami Hospital
Miami, Florida, 33136, United States
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Urology San Antonio Research
San Antonio, Texas, 78229, United States
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