Early trial combines two chemo drugs with radiation for aggressive sarcomas
NCT ID NCT04037527
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 1 trial tested a combination of two chemotherapy drugs (gemcitabine and docetaxel) given alongside radiation therapy for adults with large (over 5 cm), high-grade soft tissue sarcoma of the arms or legs. The goal was to find the safest dose and see how well the body tolerates the treatment. Only 9 people took part before the study was stopped early.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
gemcitabine and docetaxel (chemotherapy drugs) plus radiation therapy
What this could lead to
If it works, this could point toward a way to shrink large, high-grade sarcomas before surgery using a combination of chemo and radiation.
What could go wrong
This was a very early Phase 1 safety study with only 9 participants and was terminated early. The combination may cause significant side effects, and it is unknown if it will improve outcomes.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Wake Forest Baptist Comprehensive Cancer Center
Winston-Salem, North Carolina, 27157, United States