Scientists scan brains to unlock the mystery of frustration

NCT ID NCT06484088

Recruiting now Knowledge-focused Sponsor: National Institute of Mental Health (NIMH) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 6 times

Summary

This study aims to understand how the brain responds to frustration in healthy adults aged 18 to 55. Participants will undergo brain scans (MRI and MEG) while performing a task that may cause frustration. The goal is to identify brain activity patterns linked to frustration, which could eventually help develop better treatments for irritability.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could reveal brain patterns linked to frustration, pointing toward new targets for treating irritability.
What could go wrong: This is an early-phase observational study in healthy adults, not a treatment trial. Results may not apply to people with clinical irritability.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IRRITABILITY

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States
Texas A&M University
NOT_YET_RECRUITING

College Station, Texas, 77843, United States

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