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Brain scans may reveal who gets relief from knee nerve burning

NCT ID NCT07835269

Knowledge-focused Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 22, 2026 · Last updated Sep 23, 2026 · Updated 1 time

Summary

Researchers are testing whether brain activity measured with a non-invasive light-based scan can predict how well people with knee osteoarthritis respond to genicular nerve radiofrequency ablation, a procedure that uses heat to quiet pain nerves around the knee. Participants first receive a diagnostic nerve block, and those who get at least 50% pain relief go on to have the ablation. The study tracks brain activation patterns and pain questionnaires at baseline, one week, three months, and then every three months for up to a year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
genicular nerve radiofrequency ablation, a procedure that uses heat to disrupt pain nerves around the knee
What this could lead to
If brain activity patterns predict who responds to nerve ablation, doctors could one day choose the right pain treatment for each patient instead of guessing.
What could go wrong
This is a small study of 30 people, so the results may not apply broadly. Brain scans may not reliably predict pain relief, and the procedure itself carries risks like numbness or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

May 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ≥18 years old * Have osteoarthritis in either knee Exclusion Criteria: * Limited English proficiency or lack of capacity to consent (per clinical judgement) * Scheduled for knee arthroplasty within next 6 months

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Conditions

The condition(s) this trial relates to.

agnosia osteoarthritis osteoarthritis, knee Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteo arthritis of the knee Pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • St. Joseph's Hospital London

    London, Ontario, Canada

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