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Can mixing pain drugs ease recovery after major surgery?

NCT ID NCT06887153

Knowledge-focused Sponsor: Makerere University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 25, 2026 · Last updated Sep 25, 2026

Summary

Researchers at Mulago National Referral Hospital are studying how pain is managed before, during, and after major surgery in adults. They will review patient records to see how often combinations of pain medicines are used and ask patients to rate their pain every 6 hours for 24 hours after surgery. The goal is to understand whether combining pain medicines leads to better pain control than using single medicines.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If combining pain medicines works better than single drugs, hospitals could adopt these approaches to make recovery from major surgery less painful.
What could go wrong
This observational study only looks at existing records and patient ratings, so it cannot prove that one pain approach causes better outcomes. Results from one hospital may not apply elsewhere.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

449 people

The number who actually took part.

Started

Aug 2024

Finished

Feb 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients who present for surgical treatment at Mulago National Referral Hospital, Kampala City, Uganda

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients ≥18 years * Scheduled for elective orthopaedic, abdominal and thoracic surgeries * In the selected operating theatres during the study period Exclusion Criteria: * Reduced levels of consciousness or neurological deficits * ASA \>III

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Conditions

The condition(s) this trial relates to.

Pain Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain

Contacts and locations

Locations

  • Mulago National Referral Hospital

    Kampala, Uganda

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