Genetic risk profiles could change how we monitor Barrett's esophagus

NCT ID NCT07455422

First seen Mar 25, 2026 · Last updated Jun 22, 2026 · Updated 12 times

Summary

This study looks at whether sharing genetic risk information with Barrett's esophagus patients can improve their quality of life and reduce cancer worry. Researchers will collect tissue samples and use genetic analysis to create a risk model. 266 participants will be randomly assigned to either learn their risk profile or not, and all will undergo more frequent monitoring than usual.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • AZ Delta

    Roeselare, Belgium, 8800, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Antwerp University Hospital

    Edegem, Antwerpen, 2650, Belgium

  • CHU LILLE - Centre Hospitalier Universitaire de Lille

    Lille, 59000, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Ghent University Hospital (UZ Gent)

    Ghent, Belgium, 9000, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • IRCCS Ospedale San Raffaele

    Milan, Milano, 20132, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Karolinska University Hospital

    Solna, SE-171 76, Sweden

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Email: •••••@•••••

    Contact

  • Rigshospitalet

    Copenhagen, 2100, Denmark

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Sint-Augustinus Hospital (ZAS)

    Wilrijk, Antwerpen, 2610, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • St James's Hospital

    Dublin, D08 NHY1, Ireland

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University Hospital Leipzig

    Leipzig, Leipzig, 04103, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this could lead to more personalized and cost-effective surveillance strategies for Barrett's esophagus patients, reducing unnecessary procedures and anxiety.

What could go wrong

This is an early-stage observational study, not testing a treatment. The risk model may not prove accurate enough to change practice, and results may not apply to all patients.

Conditions

The condition(s) this trial relates to.

adenocarcinoma Barrett adenocarcinoma Barrett esophagus digestive system cancer esophageal adenocarcinoma gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.