Blood thinner showdown: aspirin vs. heparin for cancer surgery patients

NCT ID NCT03244020

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 28 times

Summary

This study compares two common blood thinners, aspirin and low molecular weight heparin (LMWH), to prevent dangerous blood clots after orthopedic surgery for cancer. About 2,868 adults having surgery on the pelvis or leg for bone metastases or sarcoma will be enrolled. The goal is to see which drug works better and causes fewer side effects like bleeding.

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Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Cooper University Health Care

    Camden, New Jersey, 08103, United States

  • Johns Hopkins University

    Baltimore, Maryland, 21287, United States

  • Louisiana State University Health

    New Orleans, Louisiana, 70112, United States

  • Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • Santiago Lozano-Calderon

    Boston, Massachusetts, 02114, United States

  • University of California Los Angeles Health

    Los Angeles, California, 90404, United States

  • University of Missouri-Columbia Cancer Care

    Columbia, Missouri, 65201, United States

Conditions

Explore the condition pages connected to this study.