Zhejiang Cancer Hospital

This study looks at what happens when people with HER2-positive advanced breast cancer switch between two different targeted therapy combinations after their first treatment stops working. About 600 women will be split into two groups: one switches from HP+chemo to HPy+chemo, the…

This study tests whether adding two drugs (entinostat and anlotinib) to a standard hormone therapy (fulvestrant) can shrink tumors or slow cancer growth in people with a common type of advanced breast cancer (HR+/HER2-). About 118 adults whose cancer returned or worsened after pr…

This phase 3 trial tests whether adding two immunotherapy drugs (serplulimab and bevacizumab) to a sequence of chemotherapy regimens can help people with advanced pancreatic cancer live longer. About 292 adults in China who have not had prior treatment will be randomly assigned t…

This study tests whether a single infusion of umbilical cord blood can safely raise platelet levels in cancer patients whose platelets have dropped due to chemotherapy or other cancer treatments. Researchers will enroll 25 people aged 12 to 65 and monitor their blood counts for 2…

This study tests a two-step treatment for adults with early-stage MALT lymphoma, a slow-growing cancer. First, patients get a very low dose of radiation over two days, then take a daily pill called orelabrutinib for up to 6 months. The goal is to control the disease while avoidin…

This study tests whether adding the experimental drug IBI363 to standard chemotherapy can better shrink or eliminate stomach or gastroesophageal junction cancer before surgery. It includes 60 adults aged 18-75 whose tumors lack a certain immune marker (MHC-II negative). The main …

This study tests a powerful two-step treatment for people with a fast-growing blood cancer (large B-cell lymphoma) that has come back or not responded to standard therapy. About 20 adults will receive CAR-T cells (engineered immune cells) followed by a stem cell transplant. The g…

This study tests a chemotherapy combination (albumin-bound paclitaxel and nedaplatin) given directly into the liver artery for breast cancer patients whose disease has spread only to the liver and who have not responded to standard treatments. The goal is to control liver tumors …

This study tests a combination of three drugs (thiotepa, pirtobrutinib, and sintilimab) for people with a type of brain lymphoma that has come back or is hard to treat. The goal is to see if this mix can shrink tumors and help patients live longer. About 24 adults will take part,…

This study tests a new drug combination (distamab vedotin plus carboplatin) in 20 people with advanced HER2-positive ovarian cancer who have not had chemotherapy before. The goal is to see if this combo can control the disease longer and with fewer side effects than standard trea…

This study tests an injectable imaging agent called NC527-X that makes tumors glow during surgery, helping surgeons see and remove them more precisely. About 400 adults with solid tumors who are scheduled for surgery will receive the injection before their operation. The main goa…

This study uses CT scans to see how three different breathing tubes (laryngeal masks) sit in the throat of patients under general anesthesia. Researchers want to understand which device fits best and causes the least tissue pressure. Nine adults scheduled for CT-guided procedures…

This study looks at how American ginseng changes the body's chemistry in healthy people. Twenty adults aged 18 to 45 will take 3 grams of ginseng powder daily for 14 days. Researchers will measure changes in their urine and blood to understand the herb's effects.

This study watches how normal throat structures move during a barium swallow test in people already having a routine barium meal exam. The goal is to learn more about these movements to help design better laryngeal masks, which are devices used to help patients breathe during med…

This study will look at medical records of 200 people in China with HER2-negative metastatic breast cancer who received the drug sacituzumab govitecan. The goal is to see how well the drug works and how safe it is in everyday practice, not just in controlled trials. Researchers w…