Wayne State University

This study tests whether giving choline supplements to pregnant women who do not drink alcohol can improve their babies' brain development and growth. Half the women receive a choline drink and half receive a placebo, and researchers measure infant memory, weight, and head size. …

This study tests whether giving choline supplements to pregnant women who drink heavily can reduce the negative effects of alcohol on their baby's growth and brain development. Choline is an essential nutrient that supports cell membranes and brain function. The trial compares da…

This study looks at whether Emicizumab, a newer drug, prevents bleeding during sports better than standard Factor VIII in children with moderate to severe hemophilia A. About 72 kids aged 6 to 19 who already play sports and take one of these drugs will be followed. The goal is to…

This study tests whether watching virtual reality (VR) cycling videos can produce exercise-like benefits in 48 sedentary adults with prediabetes or high blood pressure. Participants will either do 20 minutes of real cycling or watch VR cycling, and researchers will measure change…

This study looks at whether cannabis can help veterans who have PTSD and thoughts of suicide. About 500 veterans who have used cannabis in the past year will take part. Researchers will track changes in PTSD symptoms, mood, and suicide risk over time using interviews and question…

This trial tests a technology-based program called the Parenting Young Children Check-up (PYCC) for parents of children aged 2 to 5 with challenging behavior. Fifty parents from a Detroit pediatric clinic serving low-income families will be randomly assigned to either the program…

This trial tests a technology-based program called the Parenting Young Children Check-up (PYCC) for parents of children ages 2 to 5 with challenging behaviors. The program includes an initial check-up, text messages, and a website. Researchers will compare families who receive th…

This study tests whether peer recovery specialists—people who have themselves recovered from mental health or substance use problems—can effectively deliver a therapy called behavioral activation to reduce depression and substance use. The trial will enroll 250 low-income adults …

This study is testing whether adding a low or moderate dose of FDA-approved cannabidiol (Epidiolex) to cognitive behavioral therapy (CBT) helps adults with generalized anxiety disorder more than CBT plus a placebo. Researchers will measure changes in brain activity related to emo…

This study tests whether etanercept, a drug that blocks inflammation, can reduce the severity of tinnitus (ringing in the ears) caused by blast or noise exposure or traumatic brain injury. About 88 adults with moderate to severe tinnitus will receive either the drug or a placebo …

This study tests whether adding augmented reality (AR) to standard exposure therapy helps U.S. military personnel with PTSD more than therapy alone. Forty veterans or active-duty members will be split into two groups: one gets traditional therapy plus AR, the other gets therapy o…

This study will monitor 52 adults after surgery to see if the timing of opioid painkillers affects breathing problems. Participants will wear a noninvasive breathing monitor in the recovery room. The goal is to find a link between when opioids are given and drops in breathing fun…

This study is looking at 120 people who are already in treatment for abusing opioids and/or benzodiazepines (anti-anxiety drugs). Researchers want to understand why people use these drugs together, which greatly raises the risk of overdose and death. Participants will complete in…

This study is testing how opioids (morphine) and benzodiazepines (alprazolam) affect mood, anxiety, and thinking when taken alone or together. Researchers will give 24 people with a history of using these drugs single doses in a lab and measure their responses. The goal is to und…