Vanderbilt University

This study looks at whether adding the medication insulin detemir to a low-calorie diet helps people with type 2 diabetes and obesity lose more weight. It also checks how the drug affects brain areas linked to food pleasure and mood. About 240 adults aged 31-60 will be split into…

This study tests whether a mild electrical pulse on the ear can calm the racing heart and reduce symptoms like light-headedness and fatigue in people with Postural Orthostatic Tachycardia Syndrome (POTS). 18 participants will receive the stimulation while their heart rate and sym…

This study looks at liver tissue from 45 adults with nonalcoholic fatty liver disease (NAFLD) to identify which fats and proteins are present and how they change as the disease gets worse. Participants are 18–65 years old and scheduled for abdominal or bariatric surgery. The goal…

This study looks at how the body's automatic nervous system controls blood flow in the veins of the abdomen, and how this might lead to high blood pressure in people with Multiple System Atrophy (MSA). Researchers will measure vein function in about 16 adults aged 40-80 who have …

This study looks at whether a special fraction teaching program helps 4th-grade students, including those with math learning difficulties, improve their fraction skills. About 2,210 students will take part, with some teachers using the program and others teaching normally. The go…

This study looks at how the body processes prostaglandins, which are natural chemicals involved in inflammation. Researchers want to see if one prostaglandin (PGD2) can be turned into another substance (11-dehydro-TxB2) through a new, unknown pathway. Ten healthy adults who are n…

This study looks at whether adding special blood tests (biomarkers) to the usual heart-lung exam can help doctors pick the right therapy for people with pulmonary hypertension. About 100 adults undergoing a routine heart catheterization will have extra blood samples taken from th…

This study is collecting DNA, brain scans, and other biological samples from 2,000 people with major depression, bipolar disorder, or psychotic disorders, as well as healthy volunteers. The goal is to better understand the physical and genetic factors behind these conditions, whi…

This study looks at whether people with Postural Orthostatic Tachycardia Syndrome (POTS) have trouble keeping salt in their bodies compared to healthy people. Researchers will measure how much salt is in the urine and check stress hormone levels. The goal is to better understand …

This study looks at why many ICU patients develop severe muscle weakness that can last for months or years. Researchers will use muscle biopsies, ultrasound, and strength tests on 50 critically ill adults to understand the causes. The goal is to better diagnose and track this con…

This study is a registry that collects information and blood samples from over 2,400 people with atrial fibrillation who are scheduled for a heart procedure called ablation. The goal is to learn which patients benefit most from the procedure and to better understand what causes a…

This study screens people with suspected Postural Tachycardia Syndrome (POTS) and healthy volunteers to see how salt intake and hormones like aldosterone affect blood volume. Researchers want to learn if a high-salt diet can improve symptoms. No treatment is given; it is purely f…

This study looks at why people with sickle cell disease (ages 12–70) sometimes struggle to take their daily medications, such as hydroxyurea. Researchers will use surveys and interviews to understand barriers like cost, forgetfulness, or side effects. They will also ask participa…

This study compares blood samples from 212 people with and without Postural Orthostatic Tachycardia Syndrome (POTS) to see if those with POTS have more antibodies to adrenergic receptors. Researchers also want to know if these antibodies are more common in people whose POTS start…