University Of Melbourne

This study tests whether giving a clot-busting drug called tenecteplase directly into the brain artery after mechanical clot removal helps people recover better from a severe stroke. About 462 adults with a large vessel blockage in the front part of the brain will be randomly ass…

This study compares two ways to treat a torn anterior cruciate ligament (ACL): a new bracing protocol (wearing a knee brace for 12 weeks plus physiotherapy) versus early surgery. 180 people aged 16-40 with a recent ACL tear will be randomly assigned to one of the two groups. Rese…

This trial is testing a drug called tenecteplase for people with a severe stroke caused by a blockage in the basilar artery at the back of the brain. About 688 participants will receive either tenecteplase or standard care within 24 hours of symptoms starting, followed by a clot-…

This massive international trial is testing several antibiotics and treatment strategies to find the best way to reduce deaths from Staphylococcus aureus bloodstream infections. About 8,000 hospitalized adults with a confirmed staph blood infection will be randomly assigned to di…

This study is testing whether a single low dose of nivolumab, a drug used in cancer immunotherapy, can reduce the latent HIV reservoir in people living with HIV who are on antiretroviral therapy (ART). The latent reservoir is a group of dormant HIV-infected cells that current tre…

This trial tests a new, less invasive surgery to remove blood clots from the brain after a severe stroke caused by bleeding. The surgery is done within 8 hours of symptoms starting. About 240 adults with large brain bleeds will be randomly assigned to either this surgery or stand…

This study tests whether a telehealth education program, called Surgery School, helps people prepare for lung or major abdominal cancer surgery. Participants will watch videos and talk with a clinician online before their operation. The goal is to see if this reduces breathing pr…

This study compares two online treatments for Irritable Bowel Syndrome (IBS): a low-FODMAP diet program and exposure-based cognitive behavioral therapy (E-CBT). Researchers want to find out which treatment works best for different people and how they work. The study will include …

This study is looking for 530 adults with hay fever in South-Eastern Australia to help create a tool that predicts thunderstorm asthma. Participants will have allergy and lung function tests, then track their symptoms during spring for two years. The goal is to find warning signs…