University Of Leicester

This study looks at whether replacing the aortic valve early in people with severe narrowing (aortic stenosis) who have no symptoms is better than waiting until symptoms appear. About 2,844 adults over 18 with severe but symptom-free aortic stenosis will be randomly assigned to e…

This study explores whether CT and MRI scans can diagnose coronary microvascular disease (CMD), a condition where tiny heart vessels don't work properly, causing chest pain. Currently, diagnosis requires an invasive angiogram, which can be uncomfortable and risky. Researchers wil…

This study tests a new way to help people with Parkinson's improve their balance and reduce falls. Participants will play exercise video games while getting feedback on their brain activity to see if this combination works better than exercise alone. The study involves 100 people…

This study tests whether a 12-week low-calorie diet can improve heart function, reduce symptoms like breathlessness, and help people walk farther. It includes 63 adults with heart failure with preserved ejection fraction, obesity, and type 2 diabetes. Participants are randomly as…

This study looks at 130 people with a type of heart failure called HFpEF, both with and without obesity. Researchers will use CT and MRI scans, blood tests, and other checks to see if having more fat around the heart leads to worse heart function. The goal is to find new treatmen…

This study tests whether a new wearable device that uses ultrasound and light can safely and easily monitor blood flow in the brains of people who have had a stroke. Researchers will also include healthy older adults and people with dementia, depression, or delirium to compare re…

This study uses a new type of heart MRI scan with a special dye (manganese) to take detailed pictures of the heart. Researchers want to learn why people with both heart failure with preserved ejection fraction (HFpEF) and type 2 diabetes often have worse outcomes. They will compa…