University Of Leicester

This study tests whether a 12-week low-calorie meal replacement diet can improve heart function and exercise ability in people with heart failure with preserved ejection fraction (HFpEF) who are also obese. 63 adults will be randomly assigned to either the diet or standard care. …

This study tests a drug called sparsentan in 24 adults with IgA nephropathy, a kidney disease. Some participants are newly diagnosed, others have the disease return after a kidney transplant. The goal is to see if sparsentan can reduce protein in the urine, a sign of kidney damag…

This study compares two approaches for people with severe aortic stenosis who have no symptoms: early valve replacement (surgery or TAVI) versus watchful waiting. About 2,844 participants will be followed for at least 3 years to see which strategy reduces heart-related death and …

This pilot study is testing whether advanced CT and MRI scans can diagnose coronary microvascular disease (CMD) without needing an invasive angiogram. CMD affects the heart's tiny blood vessels and causes chest pain in many people with no major artery blockages. Researchers will …

This study tests whether a 12-week remote exercise program is feasible for women who have had a heart attack caused by spontaneous coronary artery dissection (SCAD). SCAD mainly affects otherwise healthy women, and standard cardiac rehab may not fit their needs. The study will me…

This study tests whether combining exercise video games (exergaming) with real-time brainwave feedback can improve balance in people with Parkinson's disease. One hundred participants will be randomly assigned to either exergaming alone or exergaming plus neurofeedback, training …

This study looks at how things like air quality, noise, and light in hospital wards affect patients' sleep. Researchers will measure these factors and track the sleep of 120 adult patients who stay at least two nights. The goal is to understand the hospital environment better and…

This study uses advanced MRI scans with a special manganese dye to look at how the heart handles calcium and energy in people with heart failure with preserved ejection fraction (HFpEF). Researchers will compare 40 people with HFpEF (half with type 2 diabetes) and 20 healthy volu…

This study is recruiting 130 people with heart failure with preserved ejection fraction (HFpEF), both obese and non-obese. Researchers will use CT and MRI scans, blood tests, and other checks to see if having more fat around the heart leads to worse heart function. The goal is to…

This study explores whether a new system using ultrasound and light sensors can remotely monitor brain blood flow in people who have had a stroke. Researchers will test the technology in 140 participants, including healthy older adults and those with stroke, dementia, depression,…