University Of Cologne

This phase 3 trial tests whether the drug dapagliflozin can slow the loss of kidney function in adults with autosomal dominant polycystic kidney disease (ADPKD), a common genetic cause of kidney failure. The study will enroll 420 people aged 18 to 60 with rapid disease progressio…

This study looks at how well vaccines against respiratory viruses (like flu or COVID-19) work in people with weakened immune systems, including those with blood cancers. Researchers will measure both antibody and T cell responses after vaccination. The goal is to understand why v…

This study looks at whether special diets—like a fasting-mimicking diet, a ketogenic diet, or a low-sulfur diet—can change the molecular makeup of kidney tissue before living donation. Researchers will analyze proteins, fats, and genetic material in kidney biopsies from 80 donors…

This study is tracking up to 2,000 people with autosomal dominant polycystic kidney disease (ADPKD) who are taking or considering tolvaptan. Researchers will collect real-world data on dosing, side effects, and kidney function over time. The goal is to understand how the drug is …

This study looks at whether giving moderate to late preterm babies skin-to-skin contact right after birth, instead of separating them, can change how their stress genes work and improve their development. About 60 babies born vaginally between 32 and 37 weeks will be randomly ass…

This study creates a global registry to collect information from 200 people with hantavirus infections. Researchers will track how the disease spreads, its symptoms, and what treatments doctors use. No new treatments are tested; the goal is to gather knowledge to improve future c…

This study creates a global registry to collect information from 200 people with leptospirosis, a bacterial infection caught from animals or contaminated water. Researchers will track how the disease spreads, what treatments work, and why some patients get very sick. No new treat…

This study looks at how the body controls sodium levels in people with end-stage kidney disease who are on dialysis. Researchers will give participants either water or a concentrated salt solution to see how their sodium levels change. The goal is to better understand hyponatremi…

This study is observing 50 adults with low sodium levels (hyponatremia) who are receiving standard hospital treatment. Researchers will measure changes in blood and urine sodium, body water, and weight over the first five days. The goal is to better understand how the body balanc…