Can a Pre-Donation diet boost kidney health?
NCT ID NCT05709600
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study looks at whether special diets—like a fasting-mimicking diet, a ketogenic diet, or a low-sulfur diet—can change the molecular makeup of kidney tissue before living donation. Researchers will analyze proteins, fats, and genetic material in kidney biopsies from 80 donors. The goal is to understand how diet might protect the kidney and improve transplant success.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Fasting mimicking diet (Prolon®), ketogenic diet, dietary restriction of sulfur-containing amino acids
- What this could lead to
- If successful, this could reveal how specific diets prepare kidneys for transplantation, potentially improving donor recovery and transplant outcomes.
- What could go wrong
- This is a small, early-stage study (80 participants) focused on molecular changes, not clinical outcomes. The diets may not produce meaningful differences, and results may not apply to all donors.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department II of Internal Medicine, Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne
RECRUITINGCologne, 50931, Germany
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