Can a diabetes drug protect kidneys in polycystic disease? new trial aims to find out
NCT ID NCT07280585
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether the drug dapagliflozin can slow the loss of kidney function in adults with autosomal dominant polycystic kidney disease (ADPKD), a common genetic cause of kidney failure. The study will enroll 420 people aged 18 to 60 with rapid disease progression. Participants will take either 10 mg of dapagliflozin or a placebo daily for 36 months, and researchers will measure changes in kidney function over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dapagliflozin (a drug that helps the kidneys remove sugar from the blood, also used for diabetes and heart failure)
What this could lead to
If it works, this could provide a new treatment option to slow kidney decline in people with polycystic kidney disease, potentially delaying the need for dialysis or transplant.
What could go wrong
This is a phase 3 trial, but the drug is already approved for other conditions. It may not slow kidney function loss in this specific disease, and side effects like urinary tract infections or dehydration are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Charite Universitaetsmedizin Berlin KöR
RECRUITINGBerlin, Germany
Contact Email: •••••@•••••
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Erasmus Universitair Medisch Centrum Rotterdam
NOT_YET_RECRUITINGRotterdam, Netherlands
Contact Email: •••••@•••••
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Fundacio Hospital Universitari Vall D'Hebron Institut De Recerca
NOT_YET_RECRUITINGBarcelona, Spain
Contact Email: •••••@•••••
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Fundacio Puigvert
NOT_YET_RECRUITINGBarcelona, Spain
Contact Email: •••••@•••••
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Goethe University Frankfurt
RECRUITINGFrankfurt, Germany
Contact Email: •••••@•••••
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Klinikum Der Landeshauptstadt Stuttgart gKAöR
RECRUITINGStuttgart, Germany
Contact Email: •••••@•••••
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Klinikum Dortmund gGmbH
RECRUITINGDortmund, Germany
Contact Email: •••••@•••••
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Klinikum Nürnberg
NOT_YET_RECRUITINGNuremberg, Bavaria, 90471, Germany
Contact Phone: •••-•••-••••
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Klinikum der Technischen Universitaet Muenchen
NOT_YET_RECRUITINGMünchen, Germany
Contact Email: •••••@•••••
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LMU Klinikum Muenchen AöR
RECRUITINGMünchen, Germany
Contact Email: •••••@•••••
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Leids Universitair Medisch Centrum
NOT_YET_RECRUITINGLeiden, Netherlands
Contact Email: •••••@•••••
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Medical Center - University of Freiburg
NOT_YET_RECRUITINGFreiburg im Breisgau, 79106, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Medizinische Hochschule Hannover
RECRUITINGHanover, Germany
Contact Email: •••••@•••••
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Medizinische Universitaet Innsbruck
RECRUITINGInnsbruck, Austria
Contact Email: •••••@•••••
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Robert Bosch Gesellschaft für Medizinische Forschung mbH
NOT_YET_RECRUITINGStuttgart, Baden-Wurttemberg, 70376, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitaet Leipzig
RECRUITINGLeipzig, Germany
Contact Email: •••••@•••••
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Universitaetsklinikum Aachen AöR
RECRUITINGAachen, Germany
Contact Email: •••••@•••••
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Universitaetsklinikum Carl Gustav Carus Dresden an der Technischen Universitaet Dresden AöR
RECRUITINGDresden, Germany
Contact Email: •••••@•••••
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Universitaetsklinikum Duesseldorf AöR
NOT_YET_RECRUITINGDüsseldorf, Germany
Contact Email: •••••@•••••
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Universitaetsklinikum Heidelberg AöR
NOT_YET_RECRUITINGHeidelberg, Germany
Contact Email: •••••@•••••
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Universitaetsklinikum Jena KöR
RECRUITINGJena, Germany
Contact Email: •••••@•••••
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Universitaetsklinikum Schleswig-Holstein AöR
NOT_YET_RECRUITINGKiel, Germany
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Universitaetsklinikum Schleswig-Holstein AöR
RECRUITINGLübeck, Germany
Contact Email: •••••@•••••
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Universitaetsmedizin Goettingen
NOT_YET_RECRUITINGGöttingen, Germany
Contact Email: •••••@•••••
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Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR
RECRUITINGMainz, Germany
Contact Email: •••••@•••••
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Universitair Medisch Centrum Groningen
RECRUITINGGroningen, Netherlands
Contact Email: •••••@•••••
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University Medical Center Hamburg-Eppendorf
NOT_YET_RECRUITINGHamburg, Germany
Contact Email: •••••@•••••
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Universitätsklinikum Köln
RECRUITINGCologne, Germany
Contact Email: •••••@•••••
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Vorarlberger Krankenhaus-Betriebsgesellschaft
NOT_YET_RECRUITINGFeldkirch, Austria
Contact Email: •••••@•••••
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Zentrum Fuer Nieren Hochdruck Und Stoffwechselerkrankungen
NOT_YET_RECRUITINGHanover, Germany
Contact Email: •••••@•••••