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Can a diabetes drug protect kidneys in polycystic disease? new trial aims to find out

NCT ID NCT07280585

Recruiting now Disease control Sponsor: University of Cologne Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 29, 2026 · Updated 3 times

Summary

This phase 3 trial tests whether the drug dapagliflozin can slow the loss of kidney function in adults with autosomal dominant polycystic kidney disease (ADPKD), a common genetic cause of kidney failure. The study will enroll 420 people aged 18 to 60 with rapid disease progression. Participants will take either 10 mg of dapagliflozin or a placebo daily for 36 months, and researchers will measure changes in kidney function over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Dapagliflozin (a drug that helps the kidneys remove sugar from the blood, also used for diabetes and heart failure)
What this could lead to
If it works, this could provide a new treatment option to slow kidney decline in people with polycystic kidney disease, potentially delaying the need for dialysis or transplant.
What could go wrong
This is a phase 3 trial, but the drug is already approved for other conditions. It may not slow kidney function loss in this specific disease, and side effects like urinary tract infections or dehydration are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autosomal dominant polycystic kidney disease polycystic kidney disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT

Contacts and locations

Locations

  • Charite Universitaetsmedizin Berlin KöR

    RECRUITING

    Berlin, Germany

  • Erasmus Universitair Medisch Centrum Rotterdam

    RECRUITING

    Rotterdam, Netherlands

  • Fundacio Hospital Universitari Vall D'Hebron Institut De Recerca

    NOT_YET_RECRUITING

    Barcelona, Spain

  • Fundacio Puigvert

    NOT_YET_RECRUITING

    Barcelona, Spain

  • Goethe University Frankfurt

    RECRUITING

    Frankfurt, Germany

  • Klinikum Der Landeshauptstadt Stuttgart gKAöR

    RECRUITING

    Stuttgart, Germany

  • Klinikum Dortmund gGmbH

    RECRUITING

    Dortmund, Germany

  • Klinikum Nürnberg

    NOT_YET_RECRUITING

    Nuremberg, Bavaria, 90471, Germany

  • Klinikum der Technischen Universitaet Muenchen

    RECRUITING

    München, Germany

  • LMU Klinikum Muenchen AöR

    RECRUITING

    München, Germany

  • Leids Universitair Medisch Centrum

    NOT_YET_RECRUITING

    Leiden, Netherlands

  • Medical Center - University of Freiburg

    NOT_YET_RECRUITING

    Freiburg im Breisgau, 79106, Germany

  • Medizinische Hochschule Hannover

    RECRUITING

    Hanover, Germany

  • Medizinische Universitaet Innsbruck

    RECRUITING

    Innsbruck, Austria

  • Robert Bosch Gesellschaft für Medizinische Forschung mbH

    RECRUITING

    Stuttgart, Baden-Wurttemberg, 70376, Germany

  • Universitaet Leipzig

    RECRUITING

    Leipzig, Germany

  • Universitaetsklinikum Aachen AöR

    RECRUITING

    Aachen, Germany

  • Universitaetsklinikum Carl Gustav Carus Dresden an der Technischen Universitaet Dresden AöR

    RECRUITING

    Dresden, Germany

  • Universitaetsklinikum Duesseldorf AöR

    RECRUITING

    Düsseldorf, Germany

  • Universitaetsklinikum Heidelberg AöR

    RECRUITING

    Heidelberg, Germany

  • Universitaetsklinikum Jena KöR

    RECRUITING

    Jena, Germany

  • Universitaetsklinikum Schleswig-Holstein AöR

    RECRUITING

    Kiel, Germany

  • Universitaetsklinikum Schleswig-Holstein AöR

    RECRUITING

    Lübeck, Germany

  • Universitaetsmedizin Goettingen

    RECRUITING

    Göttingen, Germany

  • Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR

    RECRUITING

    Mainz, Germany

  • Universitair Medisch Centrum Groningen

    RECRUITING

    Groningen, Netherlands

    Contact Email: •••••@•••••

  • University Medical Center Hamburg-Eppendorf

    RECRUITING

    Hamburg, Germany

  • Universitätsklinikum Köln

    RECRUITING

    Cologne, Germany

  • Vorarlberger Krankenhaus-Betriebsgesellschaft

    RECRUITING

    Feldkirch, Austria

  • Zentrum Fuer Nieren Hochdruck Und Stoffwechselerkrankungen

    NOT_YET_RECRUITING

    Hanover, Germany

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