Kidney disease drug under the microscope: how does tolvaptan really work?
NCT ID NCT02497521
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is tracking up to 2,000 people with autosomal dominant polycystic kidney disease (ADPKD) who are taking or considering tolvaptan. Researchers will collect real-world data on dosing, side effects, and kidney function over time. The goal is to understand how the drug is used in everyday practice and how well it works outside of controlled clinical trials.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tolvaptan
- What this could lead to
- If successful, this registry will provide real-world evidence on how tolvaptan is best used to slow kidney disease in ADPKD patients.
- What could go wrong
- This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may be influenced by differences in patient care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Charité Universitätsmedizin Berlin
ACTIVE_NOT_RECRUITINGBerlin, State of Berlin, 10117, Germany
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Fachinternistische Gemeinschaftspraxis Markgraeferland
RECRUITINGMüllheim, Baden-Wurttemberg, 79379, Germany
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Medizinische Hochschule Hannover
RECRUITINGHanover, Lower Saxony, 30625, Germany
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Nieren- und Diabeteszentrum Nettetal-Lobberich
ACTIVE_NOT_RECRUITINGNettetal, North Rhine-Westphalia, 41334, Germany
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Nierenzentrum Lübeck
RECRUITINGLübeck, Schleswig-Holstein, 23562, Germany
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Praxisgemeinschaft Dr. Peschel
RECRUITINGLeipzig, Saxony, 04107, Germany
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Robert-Bosch-Krankenhaus
RECRUITINGStuttgart, 70376, Germany
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University Hospital of Cologne
RECRUITINGCologne, North Rhine-Westphalia, 50937, Germany
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Hospital of Jena
RECRUITINGJena, Thuringia, 07747, Germany
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University Hospital of Leipzig, Nephrologische Ambulanz
RECRUITINGLeipzig, Saxony, 04103, Germany
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University Hospital of Schleswig-Holstein
RECRUITINGLübeck, Schleswig-Holstein, 23538, Germany
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University Hospital of Wuerzburg, ZIM
RECRUITINGWürzburg, Bavaria, 97080, Germany
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