Stephanie B. Seminara, Md

This early study tested whether a naturally occurring hormone called kisspeptin can stimulate reproductive hormones and help women with hypothalamic amenorrhea (a condition where periods stop due to low hormone levels) release eggs. Thirteen women received pulsatile injections of…

This study looked at how a drug that blocks opioids (naloxone) affects hormone signals in the brain related to testosterone. 23 men with a condition called hypogonadotropic hypogonadism (low testosterone) took part. The goal was to understand the body's hormone control, not to tr…

This completed Phase 2 trial tested a natural hormone called kisspeptin in 18 adults with hypogonadotropic hypogonadism, a condition where the body doesn't produce enough sex hormones. Participants received different doses of kisspeptin to see how it affected hormone pulses. The …

This study tested how well people understand genetic risk when shown different visual aids. Over 1,000 participants viewed either a single side-by-side chart or a step-by-step narrative with pictures. They then estimated their risk and answered questions about how they felt and w…

This completed Phase 1 study looked at how naloxone, an opioid blocker, affects reproductive hormones in 47 healthy adults. Participants had genetic data available from the Mass General Brigham Biobank. Researchers measured changes in luteinizing hormone pulses before and during …

This early study tested whether giving a continuous infusion of kisspeptin, a natural hormone, could dampen the overactive reproductive signals seen in polycystic ovary syndrome (PCOS). Eight women with PCOS received the hormone for 24 hours, and researchers measured changes in t…