Opioid blocker trial probes hormone secrets in biobank volunteers
NCT ID NCT04975347
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 1 study looked at how naloxone, an opioid blocker, affects reproductive hormones in 47 healthy adults. Participants had genetic data available from the Mass General Brigham Biobank. Researchers measured changes in luteinizing hormone pulses before and during naloxone infusion to understand the brain's control of reproduction.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Naloxone
- What this could lead to
- If successful, this could help explain how opioid blockers influence reproductive hormone regulation in people with certain genetic variants.
- What could go wrong
- This is a small, early-phase study in healthy volunteers, so results may not apply to people with reproductive disorders or lead to a treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.